|
🐜
|
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
192 auth.
W. V. Rheenen,
Rick A. A. van der Spek,
Mark K. Bakker,
J. Vugt,
P. Hop,
R. Zwamborn,
N. D. Klein,
H. Westra,
O. Bakker,
Patrick Deelen,
Gemma L Shireby,
E. Hannon,
M. Moisse,
D. Baird,
Restuadi Restuadi,
...
E. Dolzhenko,
Annelot M. Dekker,
Klara Gawor,
H. Westeneng,
Gijs H. P. Tazelaar,
K. V. van Eijk,
M. Kooyman,
Ross P. Byrne,
Mark A. Doherty,
M. Heverin,
Ahmad Al Khleifat,
A. Iacoangeli,
A. Shatunov,
N. Ticozzi,
Johnathan Cooper-Knock,
Bradley N. Smith,
M. Gromicho,
S. Chandran,
S. Pal,
K. Morrison,
P. Shaw,
J. Hardy,
R. Orrell,
M. Sendtner,
Thomas Meyer,
Nazlı A Başak,
A. J. van der Kooi,
A. Ratti,
I. Fogh,
C. Gellera,
Giuseppe Lauria Pinter,
S. Corti,
Cristina Cereda,
D. Sproviero,
S. D'alfonso,
G. Soraru',
G. Siciliano,
M. Filosto,
A. Padovani,
A. Chiò,
A. Calvo,
C. Moglia,
M. Brunetti,
A. Canosa,
M. Grassano,
E. Beghi,
E. Pupillo,
G. Logroscino,
B. Nefussy,
Alma Osmanovic,
Angelica Nordin,
Y. Lerner,
Michal Zabari,
M. Gotkine,
R. Baloh,
S. Bell,
P. Vourc'h,
P. Corcia,
P. Couratier,
S. Millecamps,
V. Meininger,
F. Salachas,
J. M. Pardina,
A. Assialioui,
R. Rojas‐García,
P. Dion,
J. Ross,
A. Ludolph,
Jochen H Weishaupt,
David Brenner,
A. Freischmidt,
G. Bensimon,
A. Brice,
A. Dürr,
C. Payan,
Safa Saker-Delye,
N. Wood,
S. Topp,
R. Rademakers,
L. Tittmann,
W. Lieb,
A. Franke,
S. Ripke,
A. Braun,
J. Kraft,
D. Whiteman,
C. Olsen,
A. Uitterlinden,
A. Hofman,
M. Rietschel,
S. Cichon,
M. Nöthen,
P. Amouyel,
B. Traynor,
A. Singleton,
Miguel Mitne Neto,
Ruben J. Cauchi,
R. Ophoff,
M. Wiedau-Pazos,
C. lomen-Hoerth,
V. V. Van Deerlin,
J. Grosskreutz,
A. Rödiger,
N. Gaur,
Alexander Jörk,
Tabea Barthel,
Erik Theele,
B. Ilse,
B. Stubendorff,
O. Witte,
R. Steinbach,
C. Hübner,
C. Graff,
L. Brylev,
V. Fominykh,
V. Demeshonok,
A. Ataulina,
B. Rogelj,
B. Koritnik,
J. Zidar,
M. Ravnik-Glavač,
D. Glavač,
Z. Stevic,
V. Drory,
M. Povedano,
I. Blair,
M. Kiernan,
Beben Benyamin,
R. Henderson,
S. Furlong,
S. Mathers,
P. Mccombe,
M. Needham,
S. Ngo,
G. Nicholson,
R. Pamphlett,
D. Rowe,
F. Steyn,
K. Williams,
K. Mather,
P. Sachdev,
A. Henders,
L. Wallace,
M. Carvalho,
S. Pinto,
S. Petri,
Markus Weber,
G. Rouleau,
V. Silani,
C. Curtis,
G. Breen,
J. Glass,
Robert H. Brown,
J. Landers,
C. Shaw,
P. Andersen,
E. Groen,
M. A. Es,
R. Pasterkamp,
Dongsheng Fan,
F. Garton,
A. McRae,
G. Davey Smith,
T. Gaunt,
M. Eberle,
J. Mill,
R. Mclaughlin,
O. Hardiman,
K. Kenna,
N. Wray,
E. Tsai,
H. Runz,
L. Franke,
A. Al-Chalabi,
P. Damme,
L. H. van den Berg,
J. Veldink
|
8 |
2021 |
8
🐜
|
|
🦁
|
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
17 auth.
Gemma L Shireby,
Jonathan P. Davies,
P. Francis,
Joe Burrage,
Emma M Walker,
Grant W. A. Neilson,
Aisha Dahir,
Alan J. Thomas,
S. Love,
Rebecca G. Smith,
...
K. Lunnon,
M. Kumari,
L. Schalkwyk,
K. Morgan,
K. Brookes,
E. Hannon,
J. Mill
|
6 |
2020 |
6
🦁
|
|
🐜
|
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
28 auth.
Rebecca G. Smith,
E. Pishva,
Gemma L Shireby,
Adam R. Smith,
J. Roubroeks,
E. Hannon,
Gregory Wheildon,
D. Mastroeni,
G. Gasparoni,
M. Riemenschneider,
A. Giese,
A. Sharp,
L. Schalkwyk,
V. Haroutunian,
W. Viechtbauer,
...
D. V. D. van den Hove,
M. Weedon,
Danielle L. Brokaw,
P. Francis,
Alan J. Thomas,
S. Love,
K. Morgan,
J. Walter,
P. Coleman,
D. Bennett,
P. D. De Jager,
J. Mill,
K. Lunnon
|
6 |
2020 |
6
🐜
|
|
🐜
|
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
140 auth.
P. Hop,
R. Zwamborn,
E. Hannon,
Gemma L Shireby,
Marta F. Nabais,
Emma M Walker,
W. van Rheenen,
J. V. van Vugt,
Annelot M. Dekker,
H. Westeneng,
Gijs H. P. Tazelaar,
K. V. van Eijk,
M. Moisse,
D. Baird,
A. Al Khleifat,
...
A. Iacoangeli,
N. Ticozzi,
A. Ratti,
Johnathan Cooper-Knock,
K. Morrison,
P. Shaw,
A. Başak,
A. Chiò,
A. Calvo,
C. Moglia,
A. Canosa,
M. Brunetti,
M. Grassano,
M. Gotkine,
Y. Lerner,
Michal Zabari,
P. Vourc'h,
P. Corcia,
P. Couratier,
Jesus S. Mora Pardina,
Teresa Salas,
P. Dion,
J. Ross,
R. Henderson,
S. Mathers,
P. Mccombe,
M. Needham,
G. Nicholson,
D. Rowe,
R. Pamphlett,
K. Mather,
P. Sachdev,
S. Furlong,
F. Garton,
A. Henders,
Tian Lin,
S. Ngo,
F. Steyn,
L. Wallace,
K. Williams,
Miguel Mitne Neto,
Ruben J. Cauchi,
I. Blair,
M. Kiernan,
V. Drory,
M. Povedano,
M. de Carvalho,
S. Pinto,
Markus Weber,
G. Rouleau,
V. Silani,
J. Landers,
C. Shaw,
P. Andersen,
A. McRae,
M. V. van Es,
R. Pasterkamp,
N. Wray,
R. Mclaughlin,
O. Hardiman,
K. Kenna,
E. Tsai,
H. Runz,
A. Al-Chalabi,
L. H. van den Berg,
P. van Damme,
J. Mill,
J. Veldink,
B. Heijmans,
P. ’. ’t Hoen,
J. van Meurs,
R. Jansen,
L. Franke,
D. Boomsma,
R. Pool,
J. van Dongen,
J. Hottenga,
M. V. van Greevenbroek,
Coen D. A. Stehouwer,
C. V. D. van der Kallen,
C. Schalkwijk,
C. Wijmenga,
S. Zhernakova,
E. Tigchelaar,
P. Slagboom,
M. Beekman,
J. Deelen,
D. van Heemst,
J. Veldink,
L. H. van den Berg,
C. V. van Duijn,
B. Hofman,
A. Isaacs,
A. Uitterlinden,
P. M. Jhamai,
M. Verbiest,
H. Suchiman,
M. Verkerk,
R. van der Breggen,
J. V. van Rooij,
N. Lakenberg,
H. Mei,
M. van Iterson,
M. van Galen,
J. Bot,
Dasha V Zhernakova,
Peter van ’t Hof,
Patrick Deelen,
I. Nooren,
M. Moed,
M. Vermaat,
R. Luijk,
Marc Jan Bonder,
F. van Dijk,
W. Arindrarto,
S. Kiełbasa,
M. Swertz,
E. V. van Zwet,
A. Al-Chalabi,
N. Wray,
G. Bensimon,
O. Hardiman,
A. Chiò,
G. Smith,
J. Mill
|
5 |
2022 |
5
🐜
|
|
🦁
|
DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
17 auth.
Gemma L Shireby,
E. Dempster,
Stefania Policicchio,
Rebecca G. Smith,
E. Pishva,
B. Chioza,
Jonathan P. Davies,
Joe Burrage,
K. Lunnon,
Dorothea Seiler-Vellame,
...
S. Love,
A. Thomas,
K. Brookes,
K. Morgan,
P. Francis,
E. Hannon,
J. Mill
|
5 |
2022 |
5
🦁
|
|
🐜
|
The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes
11 auth.
F. Grodstein,
B. Lemos,
Lei Yu,
Hans Klein,
Artemis Iatrou,
A. Buchman,
...
Gemma L Shireby,
J. Mill,
J. Schneider,
P. D. Jager,
D. Bennett
|
5 |
2021 |
5
🐜
|
|
🐜
|
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
13 auth.
L. Pihlstrøm,
Gemma L Shireby,
H. Geut,
S. P. Henriksen,
A. Rozemuller,
Jon-Anders Tunold,
E. Hannon,
P. Francis,
Alan J. Thomas,
S. Love,
...
J. Mill,
W. V. D. van de Berg,
M. Toft
|
4 |
2021 |
4
🐜
|
|
🐜
|
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
25 auth.
L. Steg,
Gemma L Shireby,
J. Imm,
Jonathan P. Davies,
Alice Franklin,
Robert Flynn,
Seema C Namboori,
A. Bhinge,
A. Jeffries,
Joe Burrage,
Grant W. A. Neilson,
Emma M Walker,
L. Perfect,
J. Price,
G. McAlonan,
...
D. Srivastava,
N. Bray,
Emma L. Cope,
Kimberley M. Jones,
N. Allen,
E. Pishva,
E. Dempster,
K. Lunnon,
J. Mill,
E. Hannon
|
3 |
2021 |
3
🐜
|
|
🐜
|
A comparison of blood and brain‐derived ageing and inflammation‐related DNA methylation signatures and their association with microglial burdens
22 auth.
A. Stevenson,
D. McCartney,
Gemma L Shireby,
R. Hillary,
Declan King,
Makis Tzioras,
N. Wrobel,
Sarah McCafferty,
L. Murphy,
B. McColl,
...
P. Redmond,
Adele M Taylor,
S. Harris,
T. Russ,
E. Hannon,
A. McIntosh,
J. Mill,
Colin Smith,
I. Deary,
S. Cox,
R. Marioni,
T. Spires-Jones
|
3 |
2020 |
3
🐜
|
