|
π
|
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
36 auth.
Shih-Min A. Huang,
Y. Mishina,
Shanming Liu,
Atwood K Cheung,
F. Stegmeier,
G. Michaud,
O. Charlat,
E. Wiellette,
Yue Zhang,
S. Wiessner,
M. Hild,
Xiaoying Shi,
Christopher J. Wilson,
C. Mickanin,
V. Myer,
...
A. Fazal,
R. Tomlinson,
F. Serluca,
W. Shao,
Hong Cheng,
M. Shultz,
Christina E. Rau,
M. Schirle,
J. Schlegl,
S. Ghidelli,
S. Fawell,
Chris X. Lu,
D. Curtis,
M. Kirschner,
C. Lengauer,
P. Finan,
John A. Tallarico,
T. Bouwmeester,
J. A. Porter,
A. Bauer,
Feng Cong
|
10 |
2009 |
10
π
|
|
π¦
|
Tat-mediated delivery of heterologous proteins into cells.
7 auth.
S. Fawell,
J. Seery,
Y. Daikh,
C. Moore,
C. Ling,
Pepinsky R Blake,
...
J. Barsoum
|
10 |
1994 |
10
π¦
|
|
π
|
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
43 auth.
E. Morris,
S. Jha,
C. Restaino,
P. Dayananth,
Hugh Y. Zhu,
A. Cooper,
D. Carr,
Yongi Deng,
Weihong Jin,
Stuart Black,
B. Long,
Jenny C. Liu,
Edward Dinunzio,
W. Windsor,
Rumin Zhang,
...
Shuxia Zhao,
M. Angagaw,
E. Pinheiro,
J. Desai,
L. Xiao,
G. Shipps,
A. Hruza,
James Wang,
J. Kelly,
S. Paliwal,
Xiaolei Gao,
B. S. Babu,
Liang Zhu,
Pierre Daublain,
Ling Zhang,
B. Lutterbach,
Marc Pelletier,
U. Philippar,
P. Siliphaivanh,
D. Witter,
P. Kirschmeier,
W. Bishop,
D. Hicklin,
D. Gilliland,
L. Jayaraman,
L. Zawel,
S. Fawell,
A. Samatar
|
9 |
2013 |
9
π
|
|
π¦
|
Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
S. Fawell,
J. Lees,
Roger White,
M. Parker
|
9 |
1990 |
9
π¦
|
|
π
|
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
37 auth.
A. Tron,
M. Belmonte,
Ammar Adam,
Brian Aquila,
Brian Aquila,
L. Boise,
E. Chiarparin,
Justin Cidado,
K. Embrey,
E. Gangl,
F. Gibbons,
G. Gregory,
G. Gregory,
D. Hargreaves,
J. A. Hendricks,
...
J. Johannes,
R. Johnstone,
R. Johnstone,
S. Kazmirski,
J. Kettle,
L. Michelle,
Shannon M Matulis,
A. Nooka,
M. Packer,
Bo Peng,
P. Rawlins,
Daniel W. Robbins,
A. Schuller,
Nancy Su,
Wenzhan Yang,
Q. Ye,
Xiaolan Zheng,
J. Secrist,
E. Clark,
David M. Wilson,
S. Fawell,
A. Hird
|
8 |
2018 |
8
π
|
|
π¬
|
Identification of two transactivation domains in the mouse oestrogen receptor.
J. Lees,
S. Fawell,
Malcolm G. Parker
|
8 |
1989 |
8
π¬
|
|
π¬
|
Challenges and Opportunities in Cancer Drug Resistance.
R. Ward,
S. Fawell,
Nicolas Flocβh,
V. Flemington,
D. Mckerrecher,
Paul D. Smith
|
8 |
2020 |
8
π¬
|
|
π
|
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
26 auth.
M. Menden,
Dennis Wang,
M. Mason,
B. Szalai,
K. Bulusu,
Y. Guan,
Thomas Yu,
Jaewoo Kang,
Minji Jeon,
R. Wolfinger,
Tin Nguyen,
M. Zaslavskiy,
I. S. Jang,
Z. Ghazoui,
M. Ahsen,
...
Robert M. Vogel,
E. C. Neto,
Thea C. Norman,
E. Tang,
M. Garnett,
G. Y. Veroli,
S. Fawell,
G. Stolovitzky,
J. Guinney,
J. Dry,
J. Saez-Rodriguez
|
7 |
2019 |
7
π
|
|
π
|
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
25 auth.
Jacqueline H. L. Fok,
A. Ramos-Montoya,
M. VaΜzquez-Chantada,
P. Wijnhoven,
Valeria Follia,
N. James,
Paul M. Farrington,
Ankur Karmokar,
Sophie E. Willis,
Jonathan Cairns,
J. NikkilΓ€,
D. Beattie,
Gillian M. Lamont,
M. Finlay,
Joanne Wilson,
...
Aaron Smith,
L. OβConnor,
S. Ling,
S. Fawell,
M. J. OβConnor,
S. Hollingsworth,
E. Dean,
Frederick W. Goldberg,
B. Davies,
E. Cadogan
|
7 |
2019 |
7
π
|
|
π
|
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
20 auth.
Chaoyang Sun,
Jun Yin,
Yong Fang,
Jian Chen,
K. Jeong,
Xiaohua Chen,
C. Vellano,
Z. Ju,
Wei Zhao,
Dong Zhang,
...
Yiling Lu,
F. Meric-Bernstam,
T. Yap,
M. Hattersley,
M. OβConnor,
Huawei Chen,
S. Fawell,
Shiaw-Yih Lin,
G. Peng,
G. Mills
|
7 |
2018 |
7
π
|
|
π
|
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.
19 auth.
A. Gaither,
D. Porter,
Yao Yao,
J. Borawski,
Guang Yang,
Jerry Donovan,
D. Sage,
J. Slisz,
Mary A. Tran,
C. Straub,
...
Tim Ramsey,
V. Iourgenko,
A. Huang,
Yan Chen,
R. Schlegel,
M. Labow,
S. Fawell,
W. Sellers,
L. Zawel
|
7 |
2007 |
7
π
|
|
π
|
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
28 auth.
S. Ettenberg,
O. Charlat,
Michael P. Daley,
Shanming Liu,
K. J. Vincent,
D. Stuart,
A. Schuller,
Jing Yuan,
Beatriz Ospina,
J. Green,
Qunyan Yu,
R. Walsh,
Sharon Li,
R. Schmitz,
H. Heine,
...
S. Bilic,
L. Ostrom,
Rebecca E. Mosher,
K. F. Hartlepp,
Zhen-ping Zhu,
S. Fawell,
Yung-mae M. Yao,
D. Stover,
P. Finan,
J. A. Porter,
W. Sellers,
I. Klagge,
Feng Cong
|
7 |
2010 |
7
π
|
