|
🐜
|
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
27 auth.
S. Charman,
S. Arbe-Barnes,
I. Bathurst,
R. Brun,
Michael Campbell,
W. Charman,
F. Chiu,
J. Chollet,
J. Craft,
D. Creek,
Yuxiang Dong,
H. Matile,
M. Maurer,
Julia Morizzi,
Tien Nguyen,
...
Petros Papastogiannidis,
C. Scheurer,
David M. Shackleford,
K. Sriraghavan,
L. Stingelin,
Yuanqing Tang,
H. Urwyler,
Xiaofang Wang,
K. White,
S. Wittlin,
Lin Zhou,
J. Vennerstrom
|
8 |
2011 |
8
🐜
|
|
🐜
|
Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
41 auth.
Aaron Nilsen,
Alexis N Lacrue,
K. White,
Isaac P. Forquer,
R. M. Cross,
J. Marfurt,
M. Mather,
M. Delves,
David M. Shackleford,
F. E. Sáenz,
Joanne M. Morrisey,
J. Steuten,
Tina Mutka,
Yuexin Li,
Grennady Wirjanata,
...
E. Ryan,
Sandra Duffy,
J. Kelly,
Boni F. Sebayang,
A. Zeeman,
Rintis Noviyanti,
R. Sinden,
C. Kocken,
R. Price,
V. Avery,
Iñigo Angulo-Barturen,
M. Jiménez-Díaz,
S. Ferrer,
E. Herreros,
L. Sanz,
F. Gamo,
I. Bathurst,
J. Burrows,
P. Siegl,
R. Guy,
R. Winter,
A. Vaidya,
S. Charman,
D. Kyle,
Roman Manetsch,
M. Riscoe
|
8 |
2013 |
8
🐜
|
|
🐜
|
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
25 auth.
J. Coterón,
Maria Marco,
J. Esquivias,
Xiao-Yi Deng,
K. White,
John White,
Maria Koltun,
Farah El Mazouni,
Sreekanth Kokkonda,
K. Katneni,
R. Bhamidipati,
David M. Shackleford,
Iñigo Angulo-Barturen,
S. Ferrer,
M. Jiménez-Díaz,
...
F. Gamo,
E. Goldsmith,
W. Charman,
I. Bathurst,
D. Floyd,
D. Matthews,
J. Burrows,
P. Rathod,
S. Charman,
M. Phillips
|
8 |
2011 |
8
🐜
|
|
🐜
|
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium
50 auth.
M. Jiménez-Díaz,
D. Ebert,
Yandira G. Salinas,
Anupam Pradhan,
Adele M. Lehane,
Marie-Eve Myrand-Lapierre,
Kathleen G. O’Loughlin,
David M. Shackleford,
Mariana Justino de Almeida,
A. Carrillo,
Julie Clark,
Adelaide S M Dennis,
Jonathon Diep,
Xiaoyan Deng,
Sandra Duffy,
...
A. Endsley,
Greg Fedewa,
W. A. Guiguemde,
María G. Gómez,
Gloria Holbrook,
J. Horst,
Charles C. Kim,
Jian Liu,
Marcus C. S. Lee,
A. Matheny,
M. Martínez,
Gregory E. Miller,
A. Rodríguez-Alejandre,
Laura Sanz,
M. Sigal,
Natalie J. Spillman,
P. Stein,
Z. Wang,
Fangyi Zhu,
D. Waterson,
S. Knapp,
A. Shelat,
V. Avery,
D. Fidock,
F. Gamo,
S. Charman,
J. Mirsalis,
Hongshen Ma,
S. Ferrer,
K. Kirk,
Iñigo Angulo-Barturen,
D. Kyle,
J. Derisi,
D. Floyd,
R. Guy
|
7 |
2014 |
7
🐜
|
|
🐜
|
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
13 auth.
R. Gujjar,
A. Marwaha,
Farah El Mazouni,
John White,
K. White,
S. Creason,
David M. Shackleford,
J. Baldwin,
W. Charman,
F. Buckner,
...
S. Charman,
P. Rathod,
M. Phillips
|
7 |
2009 |
7
🐜
|
|
🐜
|
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
53 auth.
Tanya Paquet,
C. Le Manach,
Diego González Cabrera,
Yassir Younis,
P. Henrich,
Tara S. Abraham,
Marcus C. S. Lee,
Rajshekhar Basak,
S. Ghidelli-Disse,
M. Lafuente-Monasterio,
M. Bantscheff,
A. Ruecker,
A. Blagborough,
S. E. Zakutansky,
A. Zeeman,
...
K. White,
David M. Shackleford,
Janne Mannila,
Julia Morizzi,
C. Scheurer,
Iñigo Angulo-Barturen,
M. Martínez,
S. Ferrer,
L. Sanz,
F. Gamo,
J. Reader,
Mariette Botha,
K. Dechering,
R. Sauerwein,
Anchalee Tungtaeng,
P. Vanachayangkul,
Chek Shik Lim,
J. Burrows,
M. Witty,
K. Marsh,
C. Bodenreider,
R. Rochford,
S. Solapure,
M. Jiménez-Díaz,
S. Wittlin,
S. Charman,
C. Donini,
B. Campo,
L. Birkholtz,
Kirsten K. Hanson,
G. Drewes,
C. Kocken,
M. Delves,
D. Leroy,
D. Fidock,
D. Waterson,
L. Street,
K. Chibale
|
7 |
2017 |
7
🐜
|
|
🐜
|
Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment
8 auth.
C. Kim-Fuchs,
C. P. Le,
M. A. Pimentel,
David M. Shackleford,
D. Ferrari,
E. Angst,
...
F. Hollande,
E. Sloan
|
7 |
2014 |
7
🐜
|
|
🐜
|
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease
27 auth.
L. Hung,
V. Villemagne,
Lesley Cheng,
Nicki A. Sherratt,
S. Ayton,
Anthony R. White,
P. Crouch,
Sinchun Lim,
S. L. Leong,
Simon J Wilkins,
J. George,
Blaine R. Roberts,
C. L. Pham,
Xiang M. Liu,
F. Chiu,
...
David M. Shackleford,
Andrew K. Powell,
C. Masters,
A. Bush,
G. O'Keefe,
J. Culvenor,
R. Cappai,
R. Cherny,
P. Donnelly,
A. Hill,
D. Finkelstein,
K. Barnham
|
7 |
2012 |
7
🐜
|
|
🐜
|
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
16 auth.
R. Gujjar,
Farah El Mazouni,
K. White,
John White,
S. Creason,
David M. Shackleford,
Xiao-Yi Deng,
W. Charman,
I. Bathurst,
J. Burrows,
...
D. Floyd,
D. Matthews,
F. Buckner,
S. Charman,
M. Phillips,
P. Rathod
|
7 |
2011 |
7
🐜
|
|
🐬
|
Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-Dose Lipid-Based Formulation to Fasted Dogs
S. Khoo,
David M. Shackleford,
C. Porter,
G. Edwards,
W. Charman
|
7 |
2003 |
7
🐬
|
|
🐜
|
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
15 auth.
B. Flynn,
G. Gill,
D. Grobelny,
J. Chaplin,
D. Paul,
A. Leske,
T. Lavranos,
D. Chalmers,
S. Charman,
E. Kostewicz,
...
David M. Shackleford,
Julia Morizzi,
E. Hamel,
M. Jung,
G. Kremmidiotis
|
7 |
2011 |
7
🐜
|
