|
🐢
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Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey
12 auth.
Maja Sedic,
Joe J. Senn,
A. Lynn,
Michael E. Laska,
Mike Smith,
S. Platz,
...
J. Bolen,
Stephen Hoge,
A. Bulychev,
E. Jacquinet,
Victoria Bartlett,
Peter Smith
|
7 |
2018 |
7
🐢
|
|
🐜
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Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties
11 auth.
Gilles Besin,
Jaclyn Milton,
S. Sabnis,
R. Howell,
C. Mihai,
K. Burke,
...
K. Benenato,
M. Stanton,
Peter Smith,
Joe J. Senn,
Stephen Hoge
|
6 |
2019 |
6
🐜
|
|
🐜
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Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
34 auth.
Maja M. Janas,
Ivan Zlatev,
Ju Liu,
Yongfeng Jiang,
Scott A. Barros,
J. Sutherland,
Wendell P. Davis,
Jingxuan Liu,
Christopher R Brown,
Xiumin Liu,
M. Schlegel,
L. Blair,
Xuemei Zhang,
Biplab Das,
C. Tran,
...
Krishna C. Aluri,
Jing Li,
S. Agarwal,
Ramesh Indrakanti,
K. Charissé,
Jayaprakash K Nair,
S. Matsuda,
K. G. Rajeev,
Tracy S. Zimmermann,
L. Sepp-Lorenzino,
Yuanxin Xu,
Akin Akinc,
K. Fitzgerald,
A. Vaishnaw,
Peter Smith,
M. Manoharan,
V. Jadhav,
Jing-tao Wu,
M. Maier
|
5 |
2019 |
5
🐜
|
|
🐜
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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
38 auth.
S. Chong,
Sagar Agarwal,
S. Agarwal,
Krishna C. Aluri,
Michael Arciprete,
Christopher R Brown,
K. Charissé,
J. Cichocki,
K. Fitzgerald,
V. Goel,
Yongli Gu,
Dale C. Guenther,
B. Habtemariam,
Vasant Jadhav,
Maja M. Janas,
...
M. Jayaraman,
J. Kurz,
Jing Li,
Steven Liou,
Ju Liu,
Xiumin Liu,
Christopher Maclauchlin,
Martin E. Maier,
M. Manoharan,
Robin McDougall,
Jayaprakash K Nair,
D. Ramsden,
G. Robbie,
Karyn M. Schmidt,
Peter Smith,
Christopher S. Theile,
A. Vaishnaw,
S. Waldron,
Jing-tao Wu,
Yuanxin Xu,
Xuemei Zhang,
Ivan Zlatev,
Elena Castellanos-Rizaldos
|
5 |
2021 |
5
🐜
|
|
🐜
|
Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine–Conjugated RNA Interference Therapeutic
15 auth.
Jing Li,
Ju Liu,
Xuemei Zhang,
Valerie A. Clausen,
C. Tran,
Michael Arciprete,
Qianfan Wang,
Carrie Rocca,
Li-Hua Guan,
Guodong Zhang,
...
Diana R Najarian,
Yuanxin Xu,
Peter Smith,
Jing-tao Wu,
S. Chong
|
4 |
2021 |
4
🐜
|
|
🐜
|
Minireview The Nonclinical Disposition and Pharmacokinetic/ Pharmacodynamic Properties of N -Acetylgalactosamine – Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human S
38 auth.
Robin McDougall,
D. Ramsden,
Sagar Agarwal,
S. Agarwal,
Krishna C. Aluri,
Michael Arciprete,
Christopher R Brown,
Elena Castellanos-Rizaldos,
K. Charissé,
S. Chong,
Joseph Cichocki,
K. Fitzgerald,
V. Goel,
Yongli Gu,
Dale C. Guenther,
...
B. Habtemariam,
Vasant Jadhav,
Maja M. Janas,
M. Jayaraman,
J. Kurz,
Jing Li,
Ju Liu,
Xiumin Liu,
Steven Liou,
Christopher Maclauchlin,
Martin E. Maier,
M. Manoharan,
K. Nair,
G. Robbie,
Karyn M. Schmidt,
Peter Smith,
Christopher S. Theile,
A. Vaishnaw,
S. Waldron,
Yuanxin Xu,
Xuemei Zhang,
Ivan Zlatev,
Jing-tao Wu
|
3 |
2022 |
3
🐜
|
|
🐜
|
Nonclinical Pharmacokinetics and ADME of Givosiran, the First Approved GalNAc-conjugated RNAi Therapeutic
15 auth.
Jing Li,
Ju Liu,
Xuemei Zhang,
Valerie A. Clausen,
C. Tran,
Michael Arciprete,
Qianfan Wang,
Carrie Rocca,
Li-Hua Guan,
Guodong Zhang,
...
Diana R Najarian,
Yuanxin Xu,
Peter Smith,
Jing Wu,
S. Chong
|
2 |
2021 |
2
🐜
|
|
🐜
|
Minireview The Nonclinical Disposition and Pharmacokinetic/ Pharmacodynamic Properties of N -Acetylgalactosamine – Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human S
38 auth.
Robin McDougall,
Diane Ramsden,
Sagar Agarwal,
S. Agarwal,
Krishna C. Aluri,
Michael Arciprete,
Christopher R Brown,
Elena Castellanos-Rizaldos,
K. Charissé,
Saeho Chong,
Joseph Cichocki,
Kevin Fitzgerald,
Varun Goel,
Yongli Gu,
Dale Guenther,
...
B. Habtemariam,
Vasant Jadhav,
Maja M. Janas,
M. Jayaraman,
Jeffrey Kurz,
Jing Li,
Ju Liu,
Xiumin Liu,
Steven Liou,
Christopher Maclauchlin,
Martin A Maier,
Muthiah Manoharan,
K. Nair,
Gabriel Robbie,
Karyn M. Schmidt,
Peter Smith,
Christopher S. Theile,
A. Vaishnaw,
S. Waldron,
Yuanxin Xu,
Xuemei Zhang,
Ivan Zlatev,
Jing Wu
|
0 |
2022 |
0
🐜
|
