|
🐜
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CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma
28 auth.
E. Hsi,
R. Steinle,
B. Balasa,
S. Szmania,
Aparna Draksharapu,
B. Shum,
M. Huseni,
David M. W. Powers,
A. Nanisetti,
Yin Zhang,
A. Rice,
Anne van Abbema,
M. Wong,
Gao Liu,
F. Zhan,
...
M. Dillon,
Shihao Chen,
S. Rhodes,
F. Fuh,
N. Tsurushita,
S. Kumar,
V. Vexler,
J. Shaughnessy,
B. Barlogie,
F. van Rhee,
M. Hussein,
D. Afar,
Marna B. Williams
|
8 |
2008 |
8
🐜
|
|
🐜
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Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
22 auth.
Y. Tai,
M. Dillon,
Weihua Song,
M. Leiba,
Xian-Feng Li,
P. Burger,
A. I. Lee,
K. Podar,
T. Hideshima,
A. Rice,
...
Anne van Abbema,
L. Jesaitis,
I. Caras,
D. Law,
E. Weller,
W. Xie,
P. Richardson,
N. Munshi,
C. Mathiot,
H. Avet-Loiseau,
D. Afar,
K. Anderson
|
8 |
2008 |
8
🐜
|
|
🐜
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Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma
19 auth.
F. van Rhee,
S. Szmania,
M. Dillon,
Anne van Abbema,
Xin Li,
Mary K Stone,
T. Garg,
Jumei Shi,
A. Moreno-Bost,
Rui Yun,
...
B. Balasa,
Bishwa Ganguly,
D. Chao,
A. Rice,
F. Zhan,
J. Shaughnessy,
B. Barlogie,
S. Yaccoby,
D. Afar
|
7 |
2009 |
7
🐜
|
|
🐜
|
A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors
24 auth.
S. Sohn,
K. Barrett,
Anne van Abbema,
Christine Chang,
P. B. Kohli,
Hidenobu Kanda,
Jan Smith,
Yingjie Lai,
Aihe Zhou,
Birong Zhang,
...
Wenqian Yang,
Karen Williams,
Calum Macleod,
Christopher A. Hurley,
J. Kulagowski,
N. Lewin‐Koh,
Hart S. Dengler,
Adam R. Johnson,
N. Ghilardi,
M. Zak,
Jun Liang,
W. Blair,
Steven Magnuson,
Lawren C. Wu
|
6 |
2013 |
6
🐜
|
|
🐜
|
Lead identification of novel and selective TYK2 inhibitors.
32 auth.
Jun Liang,
V. Tsui,
Anne van Abbema,
Liang Bao,
K. Barrett,
M. Beresini,
L. Berezhkovskiy,
W. Blair,
Christine Chang,
J. Driscoll,
C. Eigenbrot,
N. Ghilardi,
Paul Gibbons,
J. Halladay,
Adam R. Johnson,
...
P. B. Kohli,
Yingjie Lai,
M. Liimatta,
Priscilla Mantik,
Kapil Menghrajani,
J. Murray,
A. Sambrone,
Yisong Xiao,
S. Shia,
Y. Shin,
Jan Smith,
S. Sohn,
M. Stanley,
M. Ultsch,
Birong Zhang,
Lawren C. Wu,
Steven Magnuson
|
6 |
2013 |
6
🐜
|
|
🐜
|
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
30 auth.
J. Kulagowski,
W. Blair,
R. Bull,
Christine Chang,
Gauri Deshmukh,
H. Dyke,
C. Eigenbrot,
N. Ghilardi,
Paul Gibbons,
T. Harrison,
P. Hewitt,
M. Liimatta,
Christopher A. Hurley,
Adam R. Johnson,
T. Johnson,
...
J. Kenny,
Pawan Bir Kohli,
R. Maxey,
Rohan V Mendonca,
K. Mortara,
J. Murray,
R. Narukulla,
S. Shia,
M. Steffek,
S. Ubhayakar,
M. Ultsch,
Anne van Abbema,
Stuart I Ward,
B. Waszkowycz,
M. Zak
|
6 |
2012 |
6
🐜
|
|
🐜
|
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
37 auth.
Jun Liang,
Anne van Abbema,
M. Balazs,
K. Barrett,
Leo Berezhkovsky,
W. Blair,
Christine Chang,
D. Delarosa,
J. DeVoss,
J. Driscoll,
C. Eigenbrot,
N. Ghilardi,
Paul Gibbons,
J. Halladay,
Adam R. Johnson,
...
P. B. Kohli,
Yingjie Lai,
Yanzhou Liu,
J. Lyssikatos,
Priscilla Mantik,
Kapil Menghrajani,
J. Murray,
Ivan Peng,
A. Sambrone,
S. Shia,
Y. Shin,
Jan Smith,
S. Sohn,
V. Tsui,
M. Ultsch,
Lawren C. Wu,
Yisong Xiao,
Wenqian Yang,
Judy C. Young,
Birong Zhang,
B. Zhu,
Steven Magnuson
|
6 |
2013 |
6
🐜
|
|
🐜
|
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
23 auth.
Emily J. Hanan,
Anne van Abbema,
K. Barrett,
W. Blair,
J. Blaney,
Christine Chang,
C. Eigenbrot,
S. Flynn,
Paul Gibbons,
Christopher A. Hurley,
...
J. Kenny,
J. Kulagowski,
Leslie B. Lee,
Steven Magnuson,
C. Morris,
J. Murray,
Richard M Pastor,
T. Rawson,
Michael Siu,
M. Ultsch,
Aihe Zhou,
D. Sampath,
J. Lyssikatos
|
6 |
2012 |
6
🐜
|
|
🐜
|
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
47 auth.
M. Zak,
Christopher A. Hurley,
Stuart I Ward,
Philippe Bergeron,
K. Barrett,
M. Balazs,
W. Blair,
R. Bull,
Paroma Chakravarty,
Christine Chang,
P. Crackett,
Gauri Deshmukh,
J. DeVoss,
P. Dragovich,
C. Eigenbrot,
...
C. Ellwood,
S. Gaines,
N. Ghilardi,
Paul Gibbons,
S. Gradl,
P. Gribling,
C. Hamman,
E. Harstad,
P. Hewitt,
Adam R. Johnson,
T. Johnson,
J. Kenny,
M. Koehler,
Pawan Bir Kohli,
S. Labadie,
Wyne P. Lee,
Jiangpeng Liao,
M. Liimatta,
Rohan V Mendonca,
R. Narukulla,
R. Pulk,
A. Reeve,
Scott A. Savage,
S. Shia,
M. Steffek,
S. Ubhayakar,
Anne van Abbema,
I. Aliagas,
Barbara Avitabile-Woo,
Yisong Xiao,
Jing Yang,
J. Kulagowski
|
5 |
2013 |
5
🐜
|
|
🐜
|
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
44 auth.
M. Zak,
Rohan V Mendonca,
M. Balazs,
K. Barrett,
Philippe Bergeron,
W. Blair,
Christine Chang,
Gauri Deshmukh,
J. DeVoss,
P. Dragovich,
C. Eigenbrot,
N. Ghilardi,
Paul Gibbons,
S. Gradl,
C. Hamman,
...
Emily J. Hanan,
E. Harstad,
P. Hewitt,
Christopher A. Hurley,
Tian Jin,
Adam R. Johnson,
T. Johnson,
J. Kenny,
M. Koehler,
Pawan Bir Kohli,
J. Kulagowski,
S. Labadie,
Jiangpeng Liao,
M. Liimatta,
Zhonghua Lin,
P. Lupardus,
R. Maxey,
J. Murray,
R. Pulk,
Madeleine W Rodriguez,
Scott A. Savage,
S. Shia,
M. Steffek,
S. Ubhayakar,
M. Ultsch,
Anne van Abbema,
Stuart I Ward,
Ling Xiao,
Yisong Xiao
|
5 |
2012 |
5
🐜
|
