|
🐜
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Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
13 auth.
Xinmei Wen,
Wenzhi Tan,
T. Westergard,
K. Krishnamurthy,
S. Markandaiah,
Yingxiao Shi,
Shaoyu Lin,
N. Shneider,
J. Monaghan,
U. Pandey,
...
P. Pasinelli,
J. Ichida,
D. Trotti
|
8 |
2014 |
8
🐜
|
|
🦁
|
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
43 auth.
Yingxiao Shi,
Shaoyu Lin,
K. Staats,
Yichen Li,
Wen-Hsuan Chang,
Shu-Ting Hung,
Eric Hendricks,
Gabriel R. Linares,
Yaoming Wang,
Esther Y. Son,
Xinmei Wen,
Kassandra Kisler,
Brent Wilkinson,
Louise Menendez,
Tohru Sugawara,
...
Phillip E. Woolwine,
Mickey M Huang,
Michael J. Cowan,
Brandon B Ge,
N. Koutsodendris,
Kaitlin P Sandor,
Jacob Komberg,
V. Vangoor,
Ketharini Senthilkumar,
Valerie Hennes,
Carina Seah,
Amy R. Nelson,
Tze-Yuan Cheng,
S. J. Lee,
Paul R. August,
Jason A. Chen,
N. Wisniewski,
V. Hanson-Smith,
T. G. Belgard,
Alice Zhang,
M. Coba,
C. Grunseich,
Michael E. Ward,
L. H. van den Berg,
R. Pasterkamp,
D. Trotti,
B. Zlokovic,
J. Ichida
|
8 |
2018 |
8
🦁
|
|
🐜
|
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity
17 auth.
N. Kramer,
Michael S. Haney,
D. Morgens,
A. Jovičić,
A. Jovičić,
Julien Couthouis,
Amy Li,
James A. Ousey,
Rosanna K. Ma,
Gregor Bieri,
...
C. K. Tsui,
Yingxiao Shi,
Nicholas T. Hertz,
M. Tessier-Lavigne,
J. Ichida,
M. Bassik,
A. Gitler
|
7 |
2018 |
7
🐜
|
|
🐜
|
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
20 auth.
Shizuka Yamada,
Tania F. Gendron,
T. Niccoli,
Naomi R. Genuth,
Rosslyn Grosely,
Yingxiao Shi,
I. Glaria,
N. Kramer,
Lisa Nakayama,
Shirleen Fang,
...
Tai J. I. Dinger,
A. Thoeng,
Gabriel Rocha,
M. Barna,
J. Puglisi,
L. Partridge,
J. Ichida,
A. Isaacs,
L. Petrucelli,
A. Gitler
|
6 |
2019 |
6
🐜
|
|
🐜
|
Notch inhibition allows oncogene independent generation of iPS cells
16 auth.
J. Ichida,
Julia Tcw,
Luis A. Williams,
Ava C. Carter,
Yingxiao Shi,
M. T. Moura,
M. Ziller,
Sean Singh,
G. Amabile,
C. Bock,
...
A. Umezawa,
L. Rubin,
J. Bradner,
H. Akutsu,
A. Meissner,
K. Eggan
|
6 |
2014 |
6
🐜
|
|
🐜
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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
28 auth.
Shu-Ting Hung,
Gabriel R. Linares,
Wen-Hsuan Chang,
Y. Eoh,
G. Krishnan,
Stacee Mendonca,
Sarah Hong,
Yingxiao Shi,
Manuel Santana,
Chuol Kueth,
Sam Macklin-Isquierdo,
Sarah Perry,
Sarah Duhaime,
C. Maios,
Jonathan S. Chang,
...
Joscany Perez,
Alexander Couto,
Jesse D. Lai,
Yichen Li,
S. Alworth,
Eric Hendricks,
Yaoming Wang,
B. Zlokovic,
Dion K. Dickman,
J. A. Parker,
Daniela C. Zarnescu,
F. Gao,
J. Ichida
|
5 |
2023 |
5
🐜
|
|
🦁
|
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
14 auth.
Yingxiao Shi,
Shu-Ting Hung,
Gabriel Rocha,
Shaoyu Lin,
Gabriel R. Linares,
K. Staats,
Carina Seah,
Yaoming Wang,
Michael D. Chickering,
Jesse D. Lai,
...
Tohru Sugawara,
A. Sagare,
B. Zlokovic,
J. Ichida
|
5 |
2019 |
5
🦁
|
|
🐜
|
Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming.
10 auth.
Kimberley N Babos,
Kate E. Galloway,
Kassandra Kisler,
Madison Zitting,
Yichen Li,
Yingxiao Shi,
...
Brooke Quintino,
R. Chow,
B. Zlokovic,
J. Ichida
|
5 |
2019 |
5
🐜
|
|
🐜
|
Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo
18 auth.
Kim A. Staats,
Carina Seah,
A. Sahimi,
Yingfei Wang,
N. Koutsodendris,
Shaoyu Lin,
Daniel Kim,
W-H Chang,
K. Gray,
Yingxiao Shi,
...
Ya-tang Li,
Morgan Chateau,
V. Vangoor,
Ketharini Senthilkumar,
R. Pasterkamp,
Paula M Cannon,
B. Zlokovic,
J. Ichida
|
4 |
2019 |
4
🐜
|
|
🐜
|
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons
14 auth.
J. Ichida,
K. Staats,
B. Davis-Dusenbery,
Kendell Clement,
Kate E. Galloway,
Kimberly N Babos,
Yingxiao Shi,
Esther Y. Son,
E. Kiskinis,
Nicholas Atwater,
...
H. Gu,
A. Gnirke,
A. Meissner,
K. Eggan
|
3 |
2018 |
3
🐜
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