๐
|
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
196 auth.
P. Burton,
D. Clayton,
L. Cardon,
N. Craddock,
P. Deloukas,
A. Duncanson,
D. Kwiatkowski,
M. McCarthy,
W. Ouwehand,
N. Samani,
J. Todd,
P. Donnelly,
J. Barrett,
D. Davison,
D. Easton,
...
David Evans,
H. Leung,
J. Marchini,
A. Morris,
C. Spencer,
M. Tobin,
A. Attwood,
J. Boorman,
B. Cant,
Ursula Everson,
Judith M. Hussey,
J. Jolley,
A. S. Knight,
K. Koch,
Elizabeth Meech,
S. Nutland,
C. Prowse,
H. Stevens,
N. Taylor,
G. Walters,
N. Walker,
N. Watkins,
T. Winzer,
Richard W Jones,
W. McArdle,
S. Ring,
D. Strachan,
M. Pembrey,
G. Breen,
D. Clair,
S. Caesar,
K. Gordon-Smith,
L. Jones,
C. Fraser,
E. Green,
D. Grozeva,
M. Hamshere,
P. Holmans,
I. Jones,
G. Kirov,
V. Moskvina,
I. Nikolov,
M. OโDonovan,
M. Owen,
D. Collier,
A. Elkin,
A. Farmer,
R. Williamson,
P. McGuffin,
A. Young,
I. Ferrier,
S. Ball,
A. Balmforth,
J. Barrett,
D. Bishop,
M. Iles,
A. Maqbool,
N. Yuldasheva,
A. Hall,
P. Braund,
R. Dixon,
M. Mangino,
Suzanne E Stevens,
J. Thompson,
F. Bredin,
M. Tremelling,
M. Parkes,
H. Drummond,
C. Lees,
E. Nimmo,
J. Satsangi,
S. Fisher,
A. Forbes,
C. Lewis,
Clive M. Onnie,
N. Prescott,
J. Sanderson,
C. Mathew,
J. Barbour,
M. Mohiuddin,
C. Todhunter,
J. Mansfield,
T. Ahmad,
Fraser Cummings,
D. Jewell,
J. Webster,
Morris J. Brown,
G. Lathrop,
J. Connell,
A. Dominiczak,
C. Marcano,
B. Burke,
R. Dobson,
J. Gungadoo,
Kate L. Lee,
P. Munroe,
S. Newhouse,
Abiodun K Onipinla,
C. Wallace,
M. Xue,
M. Caulfield,
M. Farrall,
A. Barton,
I. Bruce,
Hannah Donovan,
S. Eyre,
Paul D. Gilbert,
S. Hider,
A. Hinks,
S. John,
C. Potter,
A. Silman,
D. Symmons,
W. Thomson,
Jane Worthington,
D. Dunger,
B. Widmer,
T. Frayling,
R. Freathy,
H. Lango,
J. Perry,
B. Shields,
M. Weedon,
A. Hattersley,
G. Hitman,
M. Walker,
K. Elliott,
C. Groves,
C. Lindgren,
N. W. Rayner,
N. Timpson,
E. Zeggini,
M. Newport,
G. Sirugo,
Emily J. Lyons,
F. Vannberg,
A. Hill,
L. Bradbury,
C. Farrar,
J. J. Pointon,
Paul Wordsworth,
M. Brown,
J. Franklyn,
J. Heward,
M. Simmonds,
S. Gough,
S. Seal,
M. Stratton,
N. Rahman,
M. Ban,
A. Goris,
S. Sawcer,
Alastair Compston,
D. Conway,
M. Jallow,
K. Rockett,
S. Bumpstead,
Amy Chaney,
K. Downes,
Mohammed J. R. Ghori,
R. Gwilliam,
S. Hunt,
M. Inouye,
A. Keniry,
E. King,
R. McGinnis,
Simon C. Potter,
R. Ravindrarajah,
P. Whittaker,
Claire Widden,
D. Withers,
Niall J. Cardin,
T. Ferreira,
Joanne Pereira-Gale,
Ingileif B. Hallgrรญmsdรณttir,
Bryan N. Howie,
Z. Su,
Y. Teo,
Damjan Vukcevic,
D. Bentley,
A. Compston
|
13 |
2007 |
13 ๐
|
๐
|
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
53 auth.
H. Ueda,
J. Howson,
L. Esposito,
J. Heward,
H. Snook,
Giselle Chamberlain,
Daniel B. Rainbow,
K. Hunter,
Annabel N. Smith,
G. Di Genova,
M. Herr,
I. Dahlman,
F. Payne,
D. Smyth,
C. Lowe,
...
R. Twells,
S. Howlett,
B. Healy,
S. Nutland,
H. Rance,
Vincent H. Everett,
L. Smink,
A. Lam,
H. Cordell,
N. Walker,
C. Bordin,
John S Hulme,
C. Motzo,
F. Cucca,
J. Hess,
M. Metzker,
J. Rogers,
S. Gregory,
A. Allahabadia,
R. Nithiyananthan,
E. Tuomilehto-Wolf,
J. Tuomilehto,
P. Bingley,
K. Gillespie,
D. Undlien,
K. Rรธnningen,
C. Guja,
C. Ionescu-Tรฎrgoviste,
D. Savage,
A. Maxwell,
D. Carson,
C. Patterson,
J. Franklyn,
D. Clayton,
L. Peterson,
L. Wicker,
J. Todd,
S. Gough
|
11 |
2003 |
11 ๐
|
๐
|
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
40 auth.
J. Todd,
N. Walker,
J. Cooper,
D. Smyth,
K. Downes,
V. Plagnol,
R. A. Bailey,
S. Nejentsev,
Sarah F. Field,
F. Payne,
C. Lowe,
Jeffrey S. Szeszko,
J. Hafler,
L. Zeitels,
Jennie H. M. Yang,
...
A. Vella,
S. Nutland,
H. Stevens,
Helen Schuilenburg,
Gillian Coleman,
M. Maisuria,
William Meadows,
L. Smink,
B. Healy,
O. Burren,
A. Lam,
Nigel R. Ovington,
James Allen,
E. Adlem,
H. Leung,
C. Wallace,
J. Howson,
C. Guja,
C. Ionescu-Tรฎrgoviste,
M. Simmonds,
J. Heward,
S. Gough,
D. Dunger,
L. Wicker,
D. Clayton
|
10 |
2007 |
10 ๐
|
๐
|
Haplotype tagging for the identification of common disease genes
21 auth.
G. Johnson,
L. Esposito,
B. J. Barratt,
Annabel N. Smith,
J. Heward,
G. D. Genova,
H. Ueda,
H. Cordell,
I. Eaves,
F. Dudbridge,
...
R. Twells,
F. Payne,
Wil Hughes,
S. Nutland,
H. Stevens,
Phill Carr,
E. Tuomilehto-Wolf,
J. Tuomilehto,
S. Gough,
D. Clayton,
J. Todd
|
10 |
2001 |
10 ๐
|
๐
|
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
92 auth.
G. Trynka,
K. Hunt,
N. Bockett,
J. Romanos,
Vanisha Mistry,
A. Szperl,
S. Bakker,
M. Bardella,
Leena Bhaw-Rosun,
G. Castillejo,
E. G. Concha,
R. Almeida,
Kerith-Rae Dias,
C. V. Diemen,
P. Dubois,
...
R. Duerr,
S. Edkins,
L. Franke,
K. Fransรฉn,
Javier Gutiรฉrrez,
Graham A. R. Heap,
B. Hrdliฤkovรก,
S. Hunt,
Leticia Plaza Izurieta,
V. Izzo,
L. Joosten,
C. Langford,
M. C. Mazzilli,
C. Mein,
V. Midah,
M. Mitroviฤ,
B. Mora,
M. Morelli,
S. Nutland,
C. Nรบรฑez,
S. Onengut-Gumuscu,
K. Pearce,
M. Platteel,
I. Polanco,
Simon C. Potter,
C. Ribes-Koninckx,
I. Ricaรฑo-Ponce,
S. Rich,
A. Rybak,
J. L. Santiago,
Sabyasachi Senapati,
A. Sood,
H. Szajewska,
R. Troncone,
J. Varadรฉ,
C. Wallace,
V. Wolters,
A. Zhernakova,
B. K. Thelma,
B. Cukrowska,
E. Urcelay,
J. Bilbao,
M. Mearin,
D. Barisani,
J. Barrett,
V. Plagnol,
P. Deloukas,
C. Wijmenga,
D. Heel,
M. Alsina,
M. E. Comas,
Laura Pardo Grau,
L. Castaรฑo,
P. Oliver,
J. C. Vitoria,
Luรญs Rodrigo,
C. Lรณpez-Larrea,
A. Lรณpez-Vรกzquez,
I. Hualde,
Z. Garcรญa,
Blanca Hernรกndez Charro,
M. Ramos-Arroyo,
F. Sรกnchez-Valverde,
C. Farrรฉ,
T. Marquรฉs,
P. Vilar,
E. Arranz,
J. A. Garrote,
R. Auricchio,
C. Esch,
A. Chmielewska,
Gosia Piescik,
E. Martรญnez,
V. Varea,
F. M. Cerezo,
E. Donat-Aliaga,
J. Escribano
|
9 |
2011 |
9 ๐
|
๐
|
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
210 auth.
S. Nejentsev,
J. Howson,
N. Walker,
Jeffrey S. Szeszko,
Sarah F. Field,
H. Stevens,
Pamela Reynolds,
Matthew Hardy,
Erna King,
J. Masters,
John S Hulme,
L. Maier,
D. Smyth,
Rebecca Bailey,
J. Cooper,
...
G. Ribas,
R. Campbell,
D. Clayton,
J. Todd,
Paul R. Burton,
L. Cardon,
N. Craddock,
P. Deloukas,
A. Duncanson,
D. Kwiatkowski,
M. McCarthy,
W. Ouwehand,
N. Samani,
P. Donnelly,
J. Barrett,
D. Davison,
D. Easton,
David Evans,
H. Leung,
J. Marchini,
Andrew P Morris,
C. Spencer,
M. Tobin,
A. Attwood,
J. Boorman,
B. Cant,
Ursula Everson,
Judith M. Hussey,
J. Jolley,
A. S. Knight,
K. Koch,
Elizabeth Meech,
S. Nutland,
C. Prowse,
N. Taylor,
G. Walters,
N. Watkins,
T. Winzer,
Richard Jones,
W. McArdle,
S. Ring,
D. Strachan,
M. Pembrey,
G. Breen,
D. Clair,
S. Caesar,
K. Gordon-Smith,
L. Jones,
C. Fraser,
E. Green,
D. Grozeva,
M. Hamshere,
P. Holmans,
I. Jones,
G. Kirov,
V. Moskvina,
I. Nikolov,
M. OโDonovan,
M. Owen,
D. A. Collier,
A. Elkin,
A. Farmer,
R. Williamson,
P. McGuffin,
A. H. Young,
I. Ferrier,
S. Ball,
A. Balmforth,
J. Barrett,
D. Bishop,
M. Iles,
A. Maqbool,
N. Yuldasheva,
A. Hall,
P. Braund,
R. Dixon,
M. Mangino,
Suzanne E Stevens,
J. Thompson,
F. Bredin,
M. Tremelling,
M. Parkes,
H. Drummond,
C. Lees,
E. Nimmo,
J. Satsangi,
S. Fisher,
A. Forbes,
C. Lewis,
Clive M. Onnie,
N. Prescott,
J. Sanderson,
C. Mathew,
J. Barbour,
M. Mohiuddin,
Catherine E. Todhunter,
J. Mansfield,
Fraser Cummings,
D. Jewell,
J. Webster,
Morris J. Brown,
G. Lathrop,
J. Connell,
A. Dominiczak,
C. Braga,
B. Burke,
Richard J. B. Dobson,
J. Gungadoo,
Kate L. Lee,
P. Munroe,
S. Newhouse,
Abiodun K Onipinla,
C. Wallace,
M. Xue,
M. Caulfield,
M. Farrall,
A. Barton,
I. Bruce,
Hannah Donovan,
S. Eyre,
Paul D. Gilbert,
S. Hider,
A. Hinks,
S. John,
C. Potter,
A. Silman,
D. Symmons,
W. Thomson,
Jane Worthington,
D. B. Dunger,
B. Widmer,
T. Frayling,
R. Freathy,
H. Lango,
J. Perry,
B. Shields,
M. Weedon,
A. Hattersley,
G. Hitman,
Mark Walker,
K. Elliott,
C. Groves,
C. Lindgren,
N. W. Rayner,
N. Timpson,
E. Zeggini,
M. Newport,
G. Sirugo,
Emily J. Lyons,
F. Vannberg,
A. Hill,
L. Bradbury,
C. Farrar,
Jennifer J. Pointon,
P. Wordsworth,
Matthew A. Brown,
J. Franklyn,
J. Heward,
M. Simmonds,
S. Gough,
S. Seal,
Michael R. Stratton,
Nazneen Rahman,
M. Ban,
A. Goris,
S. Sawcer,
Alastair Compston,
D. Conway,
M. Jallow,
K. Rockett,
C. Bryan,
S. Bumpstead,
Amy Chaney,
K. Downes,
J. Ghori,
R. Gwilliam,
S. Hunt,
M. Inouye,
A. Keniry,
Emma King,
R. McGinnis,
Simon C. Potter,
R. Ravindrarajah,
P. Whittaker,
D. Withers,
Niall J. Cardin,
T. Ferreira,
Joanne Pereira-Gale,
Ingeleif B. Hallgrimsdottir,
Bryan N. Howie,
Z. Su,
Y. Teo,
Damjan Vukcevic,
D. Bentley,
A. Compston
|
9 |
2007 |
9 ๐
|
๐
|
Population structure, differential bias and genomic control in a large-scale, case-control association study
19 auth.
D. Clayton,
N. Walker,
D. Smyth,
Rebecca Pask,
J. Cooper,
L. Maier,
L. Smink,
A. Lam,
Nigel R. Ovington,
H. Stevens,
...
S. Nutland,
J. Howson,
M. Faham,
M. Moorhead,
H. Jones,
M. Falkowski,
P. Hardenbol,
T. Willis,
J. Todd
|
9 |
2005 |
9 ๐
|
๐
|
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
23 auth.
D. Smyth,
J. Cooper,
J. Collins,
J. Heward,
J. Franklyn,
J. Howson,
A. Vella,
S. Nutland,
H. Rance,
L. Maier,
...
B. J. Barratt,
C. Guja,
C. Ionescu-Tรฎrgoviste,
D. Savage,
D. Dunger,
B. Widmer,
D. Strachan,
S. Ring,
N. Walker,
D. Clayton,
R. Twells,
S. Gough,
J. Todd
|
9 |
2004 |
9 ๐
|
๐
|
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
15 auth.
A. Vella,
J. Cooper,
C. Lowe,
N. Walker,
S. Nutland,
B. Widmer,
Richard W Jones,
S. Ring,
W. McArdle,
M. Pembrey,
...
D. Strachan,
D. Dunger,
R. Twells,
D. Clayton,
J. Todd
|
8 |
2005 |
8 ๐
|
๐
|
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
19 auth.
C. Dendrou,
V. Plagnol,
E. Fung,
Jennie H. M. Yang,
K. Downes,
J. Cooper,
S. Nutland,
Gillian Coleman,
M. Himsworth,
Matthew Hardy,
...
O. Burren,
B. Healy,
N. Walker,
K. Koch,
W. Ouwehand,
J. Bradley,
N. Wareham,
J. Todd,
L. Wicker
|
8 |
2009 |
8 ๐
|
๐
|
Parameters for reliable results in genetic association studies in common disease
23 auth.
I. Dahlman,
I. Eaves,
R. Kosoy,
V. A. Morrison,
J. Heward,
S. C. Gough,
A. Allahabadia,
J. Franklyn,
J. Tuomilehto,
E. Tuomilehto-Wolf,
...
F. Cucca,
C. Guja,
C. Ionescu-Tรฎrgoviste,
H. Stevens,
P. Carr,
S. Nutland,
P. McKinney,
J. Shield,
W. Wang,
H. Cordell,
N. Walker,
J. Todd,
P. Concannon
|
8 |
2002 |
8 ๐
|
๐
|
Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation.
14 auth.
C. Mein,
B. J. Barratt,
M. G. Dunn,
Thorsten Siegmund,
Annabel N. Smith,
L. Esposito,
S. Nutland,
H. Stevens,
A. Wilson,
M. Phillips,
...
Nancy Jarvis,
Scott M. Law,
Monika de Arruda,
J. Todd
|
7 |
2000 |
7 ๐
|
๐
|
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
37 auth.
K. Hunt,
Vanisha Mistry,
N. Bockett,
T. Ahmad,
M. Ban,
J. Barker,
J. Barrett,
H. Blackburn,
O. Brand,
O. Burren,
F. Capon,
Alastair Compston,
S. Gough,
L. Jostins,
Y. Kong,
...
James C. Lee,
M. Lek,
D. MacArthur,
J. Mansfield,
C. Mathew,
C. Mein,
M. Mirza,
S. Nutland,
S. Onengut-Gumuscu,
E. Papouli,
M. Parkes,
S. Rich,
S. Sawcer,
J. Satsangi,
M. Simmonds,
R. Trembath,
N. Walker,
E. Woลบniak,
J. Todd,
M. Simpson,
V. Plagnol,
D. V. van Heel
|
7 |
2013 |
7 ๐
|
๐
|
The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes
8 auth.
I. Eaves,
T. Merriman,
R. Barber,
S. Nutland,
E. Tuomilehto-Wolf,
J. Tuomilehto,
...
F. Cucca,
J. Todd
|
7 |
2000 |
7 ๐
|