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🐜
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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
125 auth.
D. Gordon,
Gwendolyn M. Jang,
Mehdi Bouhaddou,
Jiewei Xu,
K. Obernier,
K. White,
Matthew J. O’Meara,
V. Rezelj,
Jeffrey Z. Guo,
D. Swaney,
Tia A. Tummino,
Ruth Hüttenhain,
Robyn M. Kaake,
Alicia L. Richards,
B. Tutuncuoglu,
...
Helene Foussard,
J. Batra,
Kelsey M. Haas,
Mayank Modak,
Minkyu Kim,
Paige Haas,
Benjamin J. Polacco,
Hannes Braberg,
Jacqueline M. Fabius,
Manon Eckhardt,
Margaret Soucheray,
M. J. Bennett,
Merve Cakir,
Michael J. McGregor,
Qiongyu Li,
Bjoern Meyer,
F. Roesch,
T. Vallet,
Alice Mac Kain,
Lisa Miorin,
Elena Moreno,
Zun Zar Chi Naing,
Yuan Zhou,
S. Peng,
Ying Shi,
Ziyang Zhang,
W. Shen,
I. T. Kirby,
James E. Melnyk,
John S. Chorba,
Kevin Lou,
Shizhong A. Dai,
Inigo Barrio-Hernandez,
D. Memon,
Claudia Hernandez-Armenta,
Jiankun Lyu,
Christopher J. P. Mathy,
Tina Perica,
K. B. Pilla,
Sai J. Ganesan,
Daniel J. Saltzberg,
R. Rakesh,
Xi Liu,
S. Rosenthal,
Lorenzo Calviello,
S. Venkataramanan,
José M Liboy-Lugo,
Yizhu Lin,
Xi-Ping Huang,
Yongfeng Liu,
S. Wankowicz,
M. Bohn,
M. Safari,
Fatima S. Ugur,
C. Koh,
Nastaran Sadat Savar,
Q. D. Tran,
Djoshkun Shengjuler,
S. Fletcher,
M. C. O’Neal,
Yiming Cai,
Jason C. J. Chang,
D. Broadhurst,
Saker Klippsten,
P. P. Sharp,
Nicole A. Wenzell,
Duygu Kuzuoglu-Ozturk,
Hao-Yuan Wang,
R. Trenker,
Janet M. Young,
D. A. Cavero,
J. Hiatt,
Theodore L. Roth,
Ujjwal Rathore,
Advait Subramanian,
Julia Noack,
Mathieu Hubert,
R. Stroud,
A. Frankel,
O. Rosenberg,
K. Verba,
D. Agard,
M. Ott,
M. Emerman,
N. Jura,
M. von Zastrow,
E. Verdin,
A. Ashworth,
O. Schwartz,
C. d’Enfert,
Shaeri Mukherjee,
Matt Jacobson,
Harmit S. Malik,
D. Fujimori,
T. Ideker,
C. Craik,
S. Floor,
J. Fraser,
J. Gross,
A. Sali,
B. Roth,
D. Ruggero,
J. Taunton,
T. Kortemme,
P. Beltrão,
M. Vignuzzi,
A. García-Sastre,
K. Shokat,
B. Shoichet,
N. Krogan
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11 |
2020 |
11
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🐢
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
J. Ostrem,
U. Peters,
M. Sos,
J. Wells,
K. Shokat
|
10 |
2013 |
10
🐢
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🐬
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RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
Poulikos I. Poulikakos,
Chao Zhang,
G. Bollag,
K. Shokat,
N. Rosen
|
10 |
2010 |
10
🐬
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🐜
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IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response
9 auth.
Jonathan H. Lin,
Han Li,
D. Yasumura,
H. Cohen,
Chao Zhang,
B. Panning,
...
K. Shokat,
M. Lavail,
P. Walter
|
10 |
2007 |
10
🐜
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🐜
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The translational landscape of mTOR signalling steers cancer initiation and metastasis
19 auth.
A. Hsieh,
Yi Liu,
Merritt P. Edlind,
Nicholas T. Ingolia,
M. R. Janes,
A. Sher,
Evan Y. Shi,
C. Stumpf,
Carly Christensen,
M. Bonham,
...
Shunyou Wang,
Pingda Ren,
Michael Martin,
Katti A. Jessen,
M. Feldman,
J. Weissman,
K. Shokat,
C. Rommel,
D. Ruggero
|
10 |
2012 |
10
🐜
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🐢
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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
7 auth.
M. Feldman,
Beth Apsel,
A. Uotila,
R. Loewith,
Z. Knight,
D. Ruggero,
...
K. Shokat
|
10 |
2009 |
10
🐢
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|
🐢
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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
14 auth.
Z. Knight,
B. González,
M. Feldman,
Eli R. Zunder,
David D. Goldenberg,
O. Williams,
R. Loewith,
D. Stokoe,
A. Balla,
B. Tóth,
...
T. Balla,
W. Weiss,
Roger L. Williams,
K. Shokat
|
10 |
2006 |
10
🐢
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|
🐢
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A chemical switch for inhibitor-sensitive alleles of any protein kinase
13 auth.
Anthony C. Bishop,
Jeffrey A. Ubersax,
Dejah T. Petsch,
D. Matheos,
N. Gray,
J. Blethrow,
Eiji Shimizu,
J. Tsien,
P. Schultz,
M. Rose,
...
J. Wood,
D. Morgan,
K. Shokat
|
10 |
2000 |
10
🐢
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|
🐬
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The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule
S. Schauder,
K. Shokat,
M. Surette,
B. Bassler
|
9 |
2001 |
9
🐬
|
|
🐜
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Escape from HER family tyrosine kinase inhibitor therapy by the kinase inactive HER3
7 auth.
N. Sergina,
Megan Rausch,
Donghui Wang,
Jimmy A. Blair,
B. Hann,
K. Shokat,
...
M. Moasser
|
9 |
2007 |
9
🐜
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|
🐜
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Targets of the cyclin-dependent kinase Cdk1
8 auth.
Jeffrey A. Ubersax,
E. L. Woodbury,
P. Quang,
M. Paraz,
J. Blethrow,
K. Shah,
...
K. Shokat,
D. Morgan
|
9 |
2003 |
9
🐜
|
|
🐜
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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
13 auth.
S. Sauer,
L. Bruno,
Arnulf Hertweck,
David K. Finlay,
M. Leleu,
Mikhail Spivakov,
Z. Knight,
B. Cobb,
D. Cantrell,
Eric O'Connor,
...
K. Shokat,
A. Fisher,
M. Merkenschlager
|
9 |
2008 |
9
🐜
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|
🐜
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection
78 auth.
Mehdi Bouhaddou,
D. Memon,
Bjoern Meyer,
K. White,
V. Rezelj,
Miguel Correa Marrero,
Benjamin J. Polacco,
James E. Melnyk,
Svenja Ulferts,
Robyn M. Kaake,
J. Batra,
Alicia L. Richards,
Erica Stevenson,
D. Gordon,
Ajda Rojc,
...
K. Obernier,
Jacqueline M. Fabius,
Margaret Soucheray,
Lisa Miorin,
Elena Moreno,
C. Koh,
Q. D. Tran,
Alexandra Hardy,
R. Robinot,
T. Vallet,
Benjamin E. Nilsson-Payant,
Claudia Hernandez-Armenta,
Alistair S. Dunham,
Sebastian Weigang,
Julian Knerr,
Mayank Modak,
Diego Quintero,
Yuan Zhou,
Aurélien Dugourd,
Alberto Valdeolivas,
T. Patil,
Qiongyu Li,
Ruth Hüttenhain,
Merve Cakir,
Monita Muralidharan,
Minkyu Kim,
Gwendolyn M. Jang,
B. Tutuncuoglu,
J. Hiatt,
Jeffrey Z. Guo,
Jiewei Xu,
Sophia Bouhaddou,
Christopher J. P. Mathy,
A. Gaulton,
Emma J. Manners,
Eloy Felix,
Ying Shi,
Marisa A. Goff,
Jean K. Lim,
Timothy Mcbride,
M. C. O’Neal,
Yiming Cai,
Jason C. J. Chang,
D. Broadhurst,
Saker Klippsten,
E. de Wit,
A. Leach,
T. Kortemme,
B. Shoichet,
M. Ott,
J. Saez-Rodriguez,
B. tenOever,
R. Mullins,
E. Fischer,
G. Kochs,
R. Grosse,
A. García-Sastre,
M. Vignuzzi,
J. R. Johnson,
K. Shokat,
D. Swaney,
P. Beltrão,
N. Krogan
|
9 |
2020 |
9
🐜
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🦁
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Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
14 auth.
K. Shokat,
A. G. Nackley,
S. Shabalina,
I. E. Tchivileva,
K. Satterfield,
O. Korchynskyi,
S. S. Makarov,
W. Maixner,
A. Hoof,
Kathryn O’Donnell,
...
A. Guerrerio,
Roy Parker,
Stephen P. Miller,
Mark Lunzer
|
9 |
2006 |
9
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