S. O’Rahilly's Profile

Role	Title	Level	Year	L/R
🐢	Congenital leptin deficiency is associated with severe early-onset obesity in humans 15 auth. C. Montague, I. Farooqi, J. Whitehead, M. Soos, H. Rau, N. Wareham, C. Sewter, J. Digby, S. Mohammed, J. Hurst, ... C. Cheetham, Alison R. Earley#, A. Barnett, J. Prins, S. O’Rahilly	11	1997	11 🐢
🐢	Effects of recombinant leptin therapy in a child with congenital leptin deficiency. 9 auth. I. Farooqi, S. Jebb, Gill Langmack, E. Lawrence, C. Cheetham, A. Prentice, ... I. Hughes, M. Mccamish, S. O’Rahilly	10	1999	10 🐢
🐜	Six new loci associated with body mass index highlight a neuronal influence on body weight regulation 145 auth. C. Willer, Elizabeth K. Speliotes, R. Loos, Shengxu Li, C. Lindgren, I. Heid, S. Berndt, A. Elliott, A. Jackson, C. Lamina, G. Lettre, Noha Lim, H. Lyon, S. Mccarroll, Konstantinos Papadakis, ... L. Qi, J. Randall, R. Roccasecca, S. Sanna, P. Scheet, M. Weedon, E. Wheeler, J. Zhao, L. Jacobs, I. Prokopenko, N. Soranzo, Toshiko Tanaka, N. Timpson, P. Almgren, A. Bennett, R. Bergman, S. Bingham, L. Bonnycastle, Morris J. Brown, N. Burtt, P. Chines, L. Coin, F. Collins, J. Connell, C. Cooper, G. Smith, E. Dennison, Parimal A. Deodhar, P. Elliott, M. Erdos, K. Estrada, David M. Evans, Lauren Gianniny, C. Gieger, C. Gillson, C. Guiducci, Rachel Hackett, D. Hadley, A. Hall, A. Havulinna, J. Hebebrand, A. Hofman, B. Isomaa, K. Jacobs, T. Johnson, P. Jousilahti, Z. Jovanović, K. Khaw, P. Kraft, M. Kuokkanen, J. Kuusisto, J. Laitinen, E. Lakatta, J. Luan, R. Luben, M. Mangino, W. McArdle, T. Meitinger, A. Mulas, P. Munroe, Narisu Narisu, A. Ness, K. Northstone, S. O’Rahilly, C. Purmann, M. Rees, M. Ridderstråle, S. Ring, F. Rivadeneira, A. Ruokonen, M. Sandhu, J. Saramies, L. Scott, A. Scuteri, K. Silander, M. Sims, Kijoung Song, J. Stephens, Suzanne E Stevens, H. Stringham, Y. C. Tung, T. Valle, C. V. van Duijn, K. S. Vimaleswaran, P. Vollenweider, G. Waeber, C. Wallace, R. Watanabe, D. Waterworth, N. Watkins, J. Witteman, E. Zeggini, G. Zhai, M. Zillikens, D. Altshuler, M. Caulfield, S. Chanock, I. Farooqi, L. Ferrucci, J. Guralnik, A. Hattersley, F. Hu, M. Jarvelin, M. Laakso, V. Mooser, K. Ong, W. Ouwehand, V. Salomaa, N. Samani, T. Spector, T. Tuomi, J. Tuomilehto, M. Uda, A. Uitterlinden, N. Wareham, P. Deloukas, T. Frayling, L. Groop, R. Hayes, D. Hunter, K. Mohlke, L. Peltonen, D. Schlessinger, D. Strachan, H. Wichmann, M. McCarthy, M. Boehnke, I. Barroso, G. Abecasis, J. Hirschhorn	10	2009	10 🐜
🐢	Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. I. Farooqi, J. Keogh, G. Yeo, E. Lank, T. Cheetham, S. O’Rahilly	10	2003	10 🐢
🐢	Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. 13 auth. I. Farooqi, G. Matarese, Graham M Lord, J. Keogh, E. Lawrence, Chizo Agwu, V. Sanna, S. Jebb, F. Perna, S. Fontana, ... R. Lechler, A. DePaoli, S. O’Rahilly	10	2002	10 🐢
🐜	The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase 25 auth. T. Gerken, C. Girard, Y. C. Tung, Celia J. Webby, V. Saudek, K. Hewitson, G. Yeo, M. McDonough, Sharon Cunliffe, L. A. McNeill, J. Galvanovskis, P. Rorsman, P. Robins, X. Prieur, A. Coll, ... Marcella K. Ma, Z. Jovanović, I. Farooqi, B. Sedgwick, I. Barroso, T. Lindahl, C. Ponting, F. Ashcroft, S. O’Rahilly, C. Schofield	10	2007	10 🐜
🐜	The GPR54 Gene as a Regulator of Puberty 20 auth. S. Seminara, S. Messager, E. Chatzidaki, R. Thresher, J. Acierno, Jenna K Shagoury, Y. Bo-Abbas, W. Kuohung, K. M. Schwinof, Alan G Hendrick, ... Dirk Zahn, J. Dixon, U. Kaiser, S. Slaugenhaupt, J. Gusella, S. O’Rahilly, M. Carlton, W. Crowley, S. Aparicio, W. Colledge	10	2003	10 🐜
🐢	Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension 12 auth. I. Barroso, M. Gurnell, V. Crowley, M. Agostini, J. Schwabe, M. Soos, ... G. Maslen, T. Williams, H. Lewis, A. J. Schafer, V. Chatterjee, S. O’Rahilly	10	1999	10 🐢
🐜	Common variants near MC4R are associated with fat mass, weight and risk of obesity 101 auth. R. Loos, C. Lindgren, Shengxu Li, E. Wheeler, J. Zhao, I. Prokopenko, M. Inouye, R. Freathy, A. Attwood, J. Beckmann, S. Berndt, S. Bergmann, A. Bennett, S. Bingham, M. Bochud, ... Morris J. Brown, S. Cauchi, J. Connell, C. Cooper, G. Smith, I. Day, C. Dina, S. De, E. Dermitzakis, A. Doney, K. Elliott, P. Elliott, David M. Evans, I. Farooqi, P. Froguel, J. Ghori, C. Groves, R. Gwilliam, D. Hadley, A. Hall, A. Hattersley, J. Hebebrand, I. Heid, B. Herrera, A. Hinney, S. Hunt, M. Jarvelin, T. Johnson, J. Jolley, F. Karpe, A. Keniry, K. Khaw, R. Luben, M. Mangino, J. Marchini, W. McArdle, R. McGinnis, D. Meyre, P. Munroe, A. Morris, A. Ness, M. Neville, Alexandra C. Nica, K. Ong, S. O’Rahilly, K. Owen, C. Palmer, Konstantinos Papadakis, Simon C. Potter, A. Pouta, L. Qi, J. Randall, N. W. Rayner, S. Ring, M. Sandhu, A. Scherag, M. Sims, Kijoung Song, N. Soranzo, Elizabeth K. Speliotes, H. Syddall, S. Teichmann, N. Timpson, J. Tobias, M. Uda, C. Vogel, C. Wallace, D. Waterworth, M. Weedon, C. Willer, Vicki L. Wraight, Xin Yuan, E. Zeggini, J. Hirschhorn, D. Strachan, W. Ouwehand, M. Caulfield, N. Samani, T. Frayling, P. Vollenweider, G. Waeber, V. Mooser, P. Deloukas, M. McCarthy, N. Wareham, I. Barroso	10	2008	10 🐜
🐜	The GPR54 gene as a regulator of puberty. 20 auth. S. Seminara, S. Messager, E. Chatzidaki, R. Thresher, J. Acierno, Jenna K Shagoury, Y. Bo-Abbas, W. Kuohung, K. M. Schwinof, Alan G Hendrick, ... Dirk Zahn, J. Dixon, U. Kaiser, S. Slaugenhaupt, J. Gusella, S. O’Rahilly, M. Carlton, W. Crowley, S. Aparicio, W. Colledge	10	2004	10 🐜
🐢	A frameshift mutation in MC4R associated with dominantly inherited human obesity G. Yeo, I. Farooqi, Shiva Aminian, D. Halsall, R. Stanhope, S. O’Rahilly	10	1998	10 🐢
🐢	Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene 8 auth. R. Jackson, J. Creemers, S. Ohagi, M. Raffin-Sanson, L. Sanders, C. Montague, ... J. Hutton, S. O’Rahilly	10	1997	10 🐢
🐜	The UK10K project identifies rare variants in health and disease 242 auth. Klaudia Walter, J. Min, Jie Huang, L. Crooks, Y. Memari, Shane A. McCarthy, J. Perry, Changjiang Xu, M. Futema, D. Lawson, V. Iotchkova, S. Schiffels, A. Hendricks, P. Danecek, Rui Li, ... J. Floyd, L. Wain, I. Barroso, S. Humphries, M. Hurles, E. Zeggini, J. Barrett, V. Plagnol, J. Brent Richards, C. Greenwood, N. Timpson, R. Durbin, N. Soranzo, Sendu Bala, P. Clapham, Guy Coates, Tony Cox, A. Daly, Yuanping Du, S. Edkins, Peter J. I. Ellis, Paul Flicek, Xiaosen Guo, Xueqin Guo, Liren Huang, D. Jackson, Chris Joyce, Thomas M. Keane, Anja Kolb-Kokocinski, C. Langford, Yingrui Li, Jieqin Liang, Hong Lin, Ryan Liu, J. Maslen, Dawn Muddyman, M. Quail, J. Stalker, Jianping Sun, Jing Tian, Guangbiao Wang, Jun Wang, Yu Wang, Kim Wong, Pingbo Zhang, E. Birney, C. Boustred, Lu Chen, Gail P. Clement, M. Cocca, G. Davey Smith, I. Day, A. Day-Williams, T. Down, I. Dunham, David M. Evans, Tom R. Gaunt, Matthias Geihs, D. Hart, Bryan N. Howie, T. Hubbard, P. Hysi, Y. Jamshidi, K. Karczewski, J. Kemp, G. Lachance, M. Lek, Margarida C. Lopes, D. MacArthur, J. Marchini, M. Mangino, I. Mathieson, S. Metrustry, A. Moayyeri, K. Northstone, K. Panoutsopoulou, L. Paternoster, L. Quaye, S. Ring, G. Ritchie, Hashem A. Shihab, So-Youn Shin, K. Small, M. Soler Artigas, L. Southam, T. Spector, Beate St Pourcain, G. Surdulescu, I. Tachmazidou, M. Tobin, A. Valdes, P. Visscher, K. Ward, Scott G Wilson, Jian Yang, Feng Zhang, Houfeng Zheng, R. Anney, M. Ayub, D. Blackwood, P. Bolton, G. Breen, D. Collier, N. Craddock, S. Curran, D. Curtis, L. Gallagher, Daniel H. Geschwind, H. Gurling, P. Holmans, Irene O. Lee, J. Lönnqvist, P. McGuffin, A. McIntosh, A. McKechanie, A. McQuillin, James A. Morris, M. O’Donovan, M. Owen, A. Palotie, J. Parr, T. Paunio, O. Pietilainen, K. Rehnström, Sally Sharp, D. Skuse, D. St. Clair, J. Suvisaari, J. Walters, H. Williams, E. Bochukova, R. Bounds, A. Dominiczak, I. Farooqi, J. Keogh, G. Marenne, Andrew P Morris, S. O’Rahilly, D. Porteous, Blair H. Smith, E. Wheeler, Saeed H. Al Turki, C. Anderson, D. Antony, Phil Beales, J. Bentham, S. Bhattacharya, M. Calissano, K. Carss, K. Chatterjee, S. Çırak, Catherine Cosgrove, D. FitzPatrick, A. Reghan Foley, C. Franklin, D. Grozeva, H. Mitchison, F. Muntoni, A. Onoufriadis, V. Parker, F. Payne, F. Lucy Raymond, N. Roberts, D. Savage, P. Scambler, M. Schmidts, N. Schoenmakers, R. Semple, E. Serra, O. Spasic-Boskovic, E. Stevens, M. van Kogelenberg, Parthiban Vijayarangakannan, K. Williamson, Crispian Wilson, T. Whyte, A. Ciampi, K. Oualkacha, M. Bobrow, Heather Griffin, J. Kaye, Karen L Kennedy, A. Kent, C. Smee, R. Charlton, R. Ekong, Farrah Khawaja, L. Lopes, N. Migone, S. Payne, R. Pollitt, S. Povey, C. Ridout, R. Robinson, Richard H. Scott, A. Shaw, P. Syrris, Rohan Taylor, A. Vandersteen, A. Amuzu, J. Pablo Casas, J. Chambers, G. Dedoussis, G. Gambaro, P. Gasparini, A. Isaacs, Jon Johnson, M. Kleber, J. Kooner, C. Langenberg, J. Luan, G. Malerba, W. März, Angela Matchan, RichardJ. Morris, B. Nordestgaard, M. Benn, Robert A. Scott, D. Toniolo, M. Traglia, A. Tybjaerg-hansen, C. V. van Duijn, E. V. van Leeuwen, A. Varbo, P. Whincup, G. Zaza, Weihua Zhang	9	2015	9 🐜
🐜	The genetic architecture of type 2 diabetes 301 auth. C. Fuchsberger, J. Flannick, Tanya M. Teslovich, A. Mahajan, Vineeta Agarwala, K. Gaulton, Clement Ma, P. Fontanillas, L. Moutsianas, Davis J. McCarthy, M. Rivas, J. Perry, X. Sim, T. Blackwell, N. Robertson, ... N. Rayner, Pablo Cingolani, A. Locke, J. Fernandez Tajes, H. Highland, J. Dupuis, P. Chines, C. Lindgren, C. Hartl, A. Jackson, Han Chen, J. Huyghe, M. van de Bunt, R. Pearson, Ashish Kumar, M. Müller-Nurasyid, N. Grarup, H. Stringham, E. Gamazon, Jaehoon Lee, Yuhui Chen, R. Scott, J. Below, Peng Chen, Jinyan Huang, M. Go, M. Stitzel, D. Pasko, Stephen C. J. Parker, T. Varga, Todd Green, N. Beer, A. Day-Williams, T. Ferreira, T. Fingerlin, M. Horikoshi, Cheng Hu, Iksoo Huh, M. Ikram, Bong-Jo Kim, Yongkang Kim, Y. J. Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J. Maxwell, Yoshihiko Nagai, Xu Wang, R. Welch, Joon Yoon, Weihua Zhang, N. Barzilai, B. Voight, B. Han, C. Jenkinson, T. Kuulasmaa, J. Kuusisto, A. Manning, M. Ng, Nicholette D. Palmer, B. Balkau, A. Stančáková, H. Abboud, H. Boeing, V. Giedraitis, D. Prabhakaran, O. Gottesman, J. Scott, Jason P. Carey, P. Kwan, George B. Grant, Joshua D. Smith, B. Neale, S. Purcell, A. Butterworth, J. Howson, Heung Man Lee, Yingchang Lu, S. Kwak, Wei Zhao, J. Danesh, V. Lam, K. Park, D. Saleheen, W. So, C. H. Tam, U. Afzal, D. Aguilar, R. Arya, T. Aung, E. Chan, C. Navarro, Ching-Yu Cheng, D. Palli, A. Correa, J. Curran, Denis Rybin, V. Farook, Sharon P Fowler, B. Freedman, M. Griswold, D. Hale, P. Hicks, C. Khor, Satish Kumar, B. Lehne, Dorothée Thuillier, W. Lim, Jianjun Liu, Y. T. van der Schouw, M. Loh, S. Musani, S. Puppala, W. Scott, L. Yengo, S. Tan, H. Taylor, F. Thameem, G. Wilson, T. Wong, P. Njølstad, J. Levy, M. Mangino, L. Bonnycastle, T. Schwarzmayr, J. Fadista, G. Surdulescu, C. Herder, C. Groves, T. Wieland, J. Bork-Jensen, I. Brandslund, C. Christensen, H. Koistinen, A. Doney, L. Kinnunen, T. Esko, A. Farmer, L. Hakaste, Dylan Hodgkiss, J. Kravic, V. Lyssenko, Mette Hollensted, M. Jørgensen, T. Jørgensen, C. Ladenvall, J. Justesen, Annemari Käräjämäki, J. Kriebel, W. Rathmann, L. Lannfelt, T. Lauritzen, Narisu Narisu, A. Linneberg, O. Melander, L. Milani, M. Neville, M. Orho-Melander, L. Qi, Q. Qi, M. Roden, O. Rolandsson, A. Swift, A. Rosengren, K. Stirrups, A. Wood, E. Mihailov, C. Blancher, Mauricio O. Carneiro, J. Maguire, R. Poplin, Khalid Shakir, T. Fennell, M. DePristo, M. D. de Angelis, P. Deloukas, A. Gjesing, G. Jun, P. Nilsson, Jacquelyn Murphy, R. Onofrio, B. Thorand, T. Hansen, C. Meisinger, F. Hu, B. Isomaa, F. Karpe, L. Liang, A. Peters, C. Huth, S. O’Rahilly, C. Palmer, O. Pedersen, R. Rauramaa, J. Tuomilehto, V. Salomaa, R. Watanabe, A. Syvänen, R. Bergman, D. Bharadwaj, E. Bottinger, Y. Cho, G. Chandak, J. Chan, K. Chia, M. Daly, S. Ebrahim, C. Langenberg, P. Elliott, K. Jablonski, D. Lehman, W. Jia, R. Ma, T. Pollin, M. Sandhu, N. Tandon, P. Froguel, I. Barroso, Y. Teo, E. Zeggini, R. Loos, K. Small, J. Ried, R. DeFronzo, H. Grallert, B. Glaser, A. Metspalu, N. Wareham, M. Walker, E. Banks, C. Gieger, E. Ingelsson, H. Im, T. Illig, P. Franks, G. Buck, J. Trakalo, D. Buck, I. Prokopenko, R. Mägi, L. Lind, Y. Farjoun, K. Owen, A. Gloyn, K. Strauch, T. Tuomi, J. Kooner, Jong-Young Lee, T. Park, P. Donnelly, A. Morris, A. Hattersley, D. Bowden, F. Collins, G. Atzmon, J. Chambers, T. Spector, M. Laakso, T. Strom, G. Bell, J. Blangero, R. Duggirala, E. Tai, G. McVean, C. Hanis, James G. Wilson, Mark Seielstad, T. Frayling, J. Meigs, N. Cox, R. Sladek, E. Lander, S. Gabriel, N. Burtt, K. Mohlke, T. Meitinger, L. Groop, G. Abecasis, J. Florez, L. Scott, A. Morris, H. Kang, M. Boehnke, D. Altshuler, M. McCarthy	9	2016	9 🐜