|
π
|
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer .
34 auth.
A. Folkes,
K. Ahmadi,
W. Alderton,
Sonia Alix,
S. Baker,
G. Box,
Irina S. Chuckowree,
P. Clarke,
P. Depledge,
S. Eccles,
L. Friedman,
A. Hayes,
T. Hancox,
A. Kugendradas,
Letitia Lensun,
...
P. Moore,
A. Olivero,
Jodie Pang,
Sonal Patel,
Giles Pergl-Wilson,
F. Raynaud,
Anthony Robson,
N. Saghir,
L. Salphati,
S. Sohal,
M. Ultsch,
M. Valenti,
H. Wallweber,
N. Wan,
C. Wiesmann,
P. Workman,
A. Zhyvoloup,
M. Zvelebil,
S. Shuttleworth
|
9 |
2008 |
9
π
|
|
π
|
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
25 auth.
F. Raynaud,
S. Eccles,
P. Clarke,
A. Hayes,
B. Nutley,
Sonia Alix,
Alan T. Henley,
Francesca Di-Stefano,
Zahida Ahmad,
Sandrine Guillard,
Lynn Bjerke,
L. Kelland,
M. Valenti,
Lisa Patterson,
S. Gowan,
...
A. K. de Haven Brandon,
M. Hayakawa,
Hiroyuki Kaizawa,
Tomonubu Koizumi,
T. Ohishi,
Sonal Patel,
N. Saghir,
P. Parker,
M. Waterfield,
P. Workman
|
8 |
2007 |
8
π
|
|
π
|
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
24 auth.
F. Raynaud,
S. Eccles,
Sonal Patel,
Sonia Alix,
G. Box,
Irina S. Chuckowree,
A. Folkes,
S. Gowan,
A. K. de Haven Brandon,
F. Di Stefano,
...
A. Hayes,
Alan T. Henley,
Letitia Lensun,
Giles Pergl-Wilson,
Anthony Robson,
N. Saghir,
A. Zhyvoloup,
E. McDonald,
P. Sheldrake,
S. Shuttleworth,
M. Valenti,
N. Wan,
P. Clarke,
P. Workman
|
8 |
2009 |
8
π
|
|
π
|
Do Alterations in Placental 11Ξ²-Hydroxysteroid Dehydrogenase (11Ξ²HSD) Activities Explain Differences in Fetal Hypothalamic-Pituitary-Adrenal (HPA) Function Following Periconceptional Undernutrition or Twinning in Sheep?
9 auth.
K. Connor,
J. Challis,
P. V. van Zijl,
C. Rumball,
Sonia Alix,
A. Jaquiery,
...
M. Oliver,
J. Harding,
F. Bloomfield
|
4 |
2009 |
4
π
|
|
π’
|
Mechanism of Action of AminoCBIs: Highly Reactive but Highly Cytotoxic Analogues of the Duocarmycins
M. Tercel,
F. Pruijn,
Patrick D. OβConnor,
H. Liyanage,
G. Atwell,
Sonia Alix
|
3 |
2014 |
3
π’
|
|
π
|
Structure of PI3K gamma in complex with GDC0941
19 auth.
A. Folkes,
K. Ahmadi,
W. Alderton,
Sonia Alix,
S. Baker,
G. Box,
Irina S. Chuckowree,
P. Clarke,
P. Depledge,
S. Eccles,
...
L. Friedman,
A. Hayes,
T. Hancox,
A. Kugendradas,
Letitia Lensun,
P. Moore,
A. Olivero,
Jodie Pang,
Sonal Patel
|
0 |
2008 |
0
π
|
