|
๐
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Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
22 auth.
Ying Gao,
D. Vasilyev,
Maria B. Goncalves,
F. Howell,
C. Hobbs,
Melina Reisenberg,
Ru Shen,
Mei-Yi Zhang,
B. Strassle,
P. Lu,
...
L. Mark,
M. Piesla,
Kangwen Deng,
E. Kouranova,
R. Ring,
G. Whiteside,
B. Bates,
F. Walsh,
Gareth Williams,
M. Pangalos,
T. Samad,
P. Doherty
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8 |
2010 |
8
๐
|
|
๐
|
Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System
19 auth.
P. Chanda,
Ying Gao,
L. Mark,
Joan Btesh,
B. Strassle,
P. Lu,
M. Piesla,
Mei-Yi Zhang,
B. Bingham,
A. Uveges,
...
D. Kowal,
David S. Garbe,
E. Kouranova,
R. Ring,
B. Bates,
M. Pangalos,
J. Kennedy,
G. Whiteside,
T. Samad
|
7 |
2010 |
7
๐
|
|
๐
|
Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein ฮณ-Secretase for the Treatment of Alzheimer's Disease
36 auth.
R. Martone,
Hua Zhou,
K. Atchison,
T. Comery,
Jane Z. Xu,
Xinyi Huang,
Xioahai Gong,
Mei Jin,
A. Kreft,
B. Harrison,
S. Mayer,
S. Aschmies,
C. Gonzales,
M. Zaleska,
David R. Riddell,
...
E. Wagner,
P. Lu,
Shaiu-Ching Sun,
J. SonnenbergโReines,
A. Oganesian,
K. Adkins,
Michael W. Leach,
David W. Clarke,
D. Huryn,
M. Abou-Gharbia,
R. Magolda,
J. Bard,
G. Frick,
S. Raje,
S. Forlow,
C. Balliet,
M. Burczynski,
Peter H. Reinhart,
Hong I. Wan,
M. Pangalos,
J. Steven Jacobsen
|
7 |
2009 |
7
๐
|
|
๐
|
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
46 auth.
S. Mayer,
A. Kreft,
B. Harrison,
M. Abou-Gharbia,
M. Antane,
S. Aschmies,
K. Atchison,
M. Chlenov,
Derek C. Cole,
T. Comery,
G. Diamantidis,
J. Ellingboe,
K. Fan,
R. Galante,
C. Gonzales,
...
Douglas M. Ho,
Molly Hoke,
Yun Hu,
D. Huryn,
Uday Jain,
Mei Jin,
K. Kremer,
D. Kubrak,
Melissa Lin,
P. Lu,
R. Magolda,
R. Martone,
William J. Moore,
A. Oganesian,
M. Pangalos,
A. Porte,
P. Reinhart,
L. Resnick,
David R. Riddell,
J. SonnenbergโReines,
J. Stock,
Shaiu-Ching Sun,
E. Wagner,
T. Wang,
Kevin R. Woller,
Zheng Xu,
M. Zaleska,
Joseph Zeldis,
Minsheng Zhang,
Hua Zhou,
J. Steven Jacobsen
|
6 |
2008 |
6
๐
|
|
๐
|
Speciesโspecific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers
16 auth.
B. Bingham,
Philip G. Jones,
A. Uveges,
S. Kotnis,
P. Lu,
V. Smith,
Shaiu-Ching Sun,
L. Resnick,
M. Chlenov,
Y. He,
...
B. Strassle,
T. Cummons,
M. Piesla,
J. Harrison,
G. Whiteside,
J. Kennedy
|
6 |
2007 |
6
๐
|
|
๐ฌ
|
The persistence of a long-term negative affective state following the induction of either acute or chronic pain
M. Hummel,
P. Lu,
T. Cummons,
G. Whiteside
|
6 |
2008 |
6
๐ฌ
|
|
๐
|
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models
7 auth.
M. Piesla,
L. Leventhal,
B. Strassle,
J. Harrison,
T. Cummons,
P. Lu,
...
G. Whiteside
|
5 |
2009 |
5
๐
|
|
๐
|
Pain is a salient โstressorโ that is mediated by corticotropin-releasing factor-1 receptors
7 auth.
M. Hummel,
T. Cummons,
P. Lu,
L. Mark,
J. Harrison,
J. Kennedy,
...
G. Whiteside
|
5 |
2010 |
5
๐
|
|
๐ฆ
|
CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system.
7 auth.
P. Lu,
C. Gonzales,
Yi Chen,
A. Adedoyin,
M. Hummel,
J. Kennedy,
...
G. Whiteside
|
5 |
2009 |
5
๐ฆ
|
|
๐
|
Pharmacological Characterization of the Muscarinic Agonist (3R,4R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in Vitro and in Vivo Models of Chronic Pain
18 auth.
N. R. Sullivan,
L. Leventhal,
J. Harrison,
V. Smith,
T. Cummons,
T. Spangler,
Shaiu-Ching Sun,
P. Lu,
A. Uveges,
B. Strassle,
...
M. Piesla,
Rana Ramdass,
Alena Barry,
Jonathan Schantz,
W. Adams,
G. Whiteside,
A. Adedoyin,
Philip G. Jones
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4 |
2007 |
4
๐
|
