|
π
|
Electrophilic properties of itaconate and derivatives regulate the IΞΊBΞΆβATF3 inflammatory axis
31 auth.
M. Bambouskova,
L. Gorvel,
Vicky Lampropoulou,
A. Sergushichev,
Ekaterina Loginicheva,
Kendall Johnson,
D. Korenfeld,
M. Mathyer,
HyeRyun Kim,
LiβHao Huang,
Dustin Duncan,
H. Bregman,
Abdurrahman Keskin,
A. Santeford,
R. Apte,
...
Raghav Sehgal,
Britney Johnson,
G. Amarasinghe,
M. Soares,
T. Satoh,
S. Akira,
Tsonwin Hai,
Cristina Guzman Strong,
K. Auclair,
T. Roddy,
S. Biller,
M. JovanoviΔ,
E. Klechevsky,
Kelly M. Stewart,
G. Randolph,
M. Artyomov
|
8 |
2018 |
8
π
|
|
π
|
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
37 auth.
Janeta Popovici-Muller,
R. Lemieux,
Erin Artin,
J. Saunders,
F. Salituro,
J. Travins,
Giovanni Cianchetta,
Z. Cai,
Ding Zhou,
D. Cui,
Ping Chen,
K. Straley,
E. Tobin,
F. Wang,
M. David,
...
V. Penard-Lacronique,
C. Quivoron,
V. Saada,
S. de Botton,
S. Gross,
L. Dang,
Hua Yang,
L. Utley,
Yue Chen,
HyeRyun Kim,
Shengfang Jin,
Zhiwei Gu,
Gui Yao,
Zhiyong Luo,
Xiaobing Lv,
Cheng Fang,
Liping Yan,
A. Olaharski,
L. Silverman,
S. Biller,
Shinsan M. Su,
K. Yen
|
8 |
2018 |
8
π
|
|
π
|
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells.
21 auth.
Eric H. Ma,
Mark J. Verway,
Radia M. Johnson,
D. Roy,
Mya Steadman,
Sebastian Hayes,
Kelsey S. Williams,
Ryan D. Sheldon,
B. Samborska,
P. Kosinski,
...
HyeRyun Kim,
Takla Griss,
B. Faubert,
Stephanie A Condotta,
C. Krawczyk,
R. Deberardinis,
Kelly M. Stewart,
M. Richer,
V. Chubukov,
T. Roddy,
Russell G. Jones
|
8 |
2019 |
8
π
|
|
π
|
Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages
11 auth.
A. Swain,
M. Bambouskova,
HyeRyun Kim,
P. Andhey,
Dustin Duncan,
K. Auclair,
...
V. Chubukov,
D. M. Simons,
T. Roddy,
Kelly M. Stewart,
M. Artyomov
|
7 |
2020 |
7
π
|
|
π
|
Itaconate confers tolerance to late NLRP3 inflammasome activation
22 auth.
M. Bambouskova,
L. Potuckova,
Tomas Paulenda,
Martina Kerndl,
D. Mogilenko,
Kate Lizotte,
A. Swain,
Sebastian Hayes,
Ryan D. Sheldon,
HyeRyun Kim,
...
Unnati Kapadnis,
Abigail E. Ellis,
Christine N. Isaguirre,
S. Burdess,
Anwesha Laha,
G. Amarasinghe,
V. Chubukov,
T. Roddy,
M. Diamond,
Russell G. Jones,
D. M. Simons,
M. Artyomov
|
7 |
2021 |
7
π
|
|
π
|
Imaging , Diagnosis , Prognosis CirculatingOncometabolite 2-Hydroxyglutarate Is aPotential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma
30 auth.
D. Borger,
L. Goyal,
T. Yau,
R. Poon,
M. Ancukiewicz,
V. Deshpande,
D. Christiani,
Hannah M. Liebman,
Hua Yang,
HyeRyun Kim,
K. Yen,
J. Faris,
A. Iafrate,
E. Kwak,
J. Clark,
...
Jill N. Allen,
L. Blaszkowsky,
Janet E. Murphy,
Supriya K. Saha,
T. Hong,
J. Wo,
C. Ferrone,
K. Tanabe,
N. Bardeesy,
K. Straley,
S. Agresta,
D. Schenkein,
L. Ellisen,
D. Ryan,
A. Zhu
|
6 |
2014 |
6
π
|
|
π
|
Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.
15 auth.
A. Fathi,
H. Sadrzadeh,
A. Comander,
M. Higgins,
A. Bardia,
A. Perry,
M. Burke,
Regina Silver,
Christina R. Matulis,
K. Straley,
...
K. Yen,
S. Agresta,
HyeRyun Kim,
D. Schenkein,
D. Borger
|
6 |
2014 |
6
π
|
|
π
|
Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for therapy by mitapivat.
14 auth.
M. Rab,
J. Bos,
B. V. van Oirschot,
S. van Straaten,
P. Kosinski,
V. Chubukov,
HyeRyun Kim,
H. Mangus,
R. Schutgens,
G. Pasterkamp,
...
L. Dang,
C. Kung,
E. V. van Beers,
R. van Wijk
|
4 |
2021 |
4
π
|
|
π
|
AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model
19 auth.
C. Quivoron,
M. David,
K. Straley,
J. Travins,
HyeRyun Kim,
Yue Chen,
Dongwei Zhu,
V. Saada,
O. Bawa,
P. Opolon,
...
MΓ©lanie Polrot,
J. Micol,
C. Willekens,
O. Bernard,
Hua Yang,
S. Agresta,
S. Botton,
K. Yen,
V. Penard-Lacronique
|
4 |
2014 |
4
π
|
|
π
|
Abstract B126: AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies
20 auth.
K. Yen,
Z. Konteatis,
Zhihua Sui,
Erin Artin,
L. Dang,
K. Straley,
E. Tobin,
Carl Campos,
Hua Yang,
R. Nagaraja,
...
Yue Chen,
HyeRyun Kim,
C. Gliser,
Brandon Nicolay,
A. Olaharski,
L. Silverman,
S. Biller,
Shinsan M. Su,
I. Mellinghoff,
Janeta Popovici-Muller
|
3 |
2018 |
3
π
|
