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🦁
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Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase*
11 auth.
K. Qian,
Lian Wang,
E. Hickey,
J. Studts,
K. Barringer,
Charline Peng,
...
Anthony Kronkaitis,
Jun Li,
André White,
S. Mische,
B. Farmer
|
8 |
2005 |
8
🦁
|
|
🐜
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Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.
31 auth.
C. Kung,
J. Hixon,
S. Choe,
K. Marks,
S. Gross,
Erin Murphy,
B. Delabarre,
Giovanni Cianchetta,
Shalini Sethumadhavan,
Xiling Wang,
Shunqi Yan,
Yi Gao,
Cheng Fang,
Wentao Wei,
F. Jiang,
...
Shaohui Wang,
K. Qian,
J. Saunders,
E. Driggers,
H. Woo,
K. Kunii,
Stuart Murray,
Hua Yang,
K. Yen,
Wei Liu,
L. Cantley,
M. V. Vander Heiden,
Shinsan M. Su,
Shengfang Jin,
F. Salituro,
L. Dang
|
7 |
2012 |
7
🐜
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|
🦁
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Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.
19 auth.
K. Qian,
Lian Wang,
C. Cywin,
B. Farmer,
E. Hickey,
C. Homon,
S. Jakes,
M. Kashem,
George Lee,
S. Leonard,
...
Jun Li,
Ronald Magboo,
Wang Mao,
E. Pack,
Charlene Peng,
Anthony S. Prokopowicz,
Morgan Welzel,
J. Wolak,
T. Morwick
|
5 |
2009 |
5
🦁
|
|
🐜
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Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.
23 auth.
Jiang-Ping Wu,
J. Emeigh,
D. A. Gao,
D. Goldberg,
D. Kuzmich,
C. Miao,
Ian Potocki,
K. Qian,
R. Sorcek,
D. Jeanfavre,
...
Keiichi Kishimoto,
E. Mainolfi,
G. Nabozny,
Charline Peng,
P. Reilly,
R. Rothlein,
R. Sellati,
J. Woska,
Shirlynn Chen,
Jocelyn A Gunn,
Drané O'Brien,
S. Norris,
T. A. Kelly
|
4 |
2004 |
4
🐜
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|
🦁
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Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase.
10 auth.
K. Qian,
J. Studts,
Lian Wang,
K. Barringer,
Anthony Kronkaitis,
Charline Peng,
...
Alistair Baptiste,
R. LaFrance,
S. Mische,
B. Farmer
|
4 |
2005 |
4
🦁
|
|
🐜
|
Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase.
13 auth.
A. Hammach,
Antonio Barbosa,
F. Gaenzler,
Tazmeen N Fadra,
D. Goldberg,
M. Hao,
Rachel R. Kroe,
Pingrong Liu,
K. Qian,
M. Ralph,
...
Christopher Sarko,
Fariba Soleymanzadeh,
N. Moss
|
4 |
2006 |
4
🐜
|
|
🐜
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Discovery and optimization of p38 inhibitors via computer-assisted drug design.
23 auth.
D. Goldberg,
M. Hao,
K. Qian,
A. Swinamer,
D. A. Gao,
Zhaoming Xiong,
Christopher Sarko,
Angela K Berry,
John W Lord,
R. Magolda,
...
Tazmeen N Fadra,
Rachel R. Kroe,
Alison J Kukulka,
J. Madwed,
Leslie Martin,
C. Pargellis,
D. Skow,
Jinhua J. Song,
Zhulin Tan,
C. Torcellini,
Clare Zimmitti,
N. Yee,
N. Moss
|
4 |
2007 |
4
🐜
|
|
🐜
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Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase.
11 auth.
D. Cogan,
R. A. Aungst,
E. Breinlinger,
Tazmeen N Fadra,
D. Goldberg,
M. Hao,
...
Rachel R. Kroe,
N. Moss,
C. Pargellis,
K. Qian,
A. Swinamer
|
4 |
2008 |
4
🐜
|
|
🐜
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Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.
15 auth.
H. Lo,
P. Nemoto,
J. M. Kim,
M. Hao,
K. Qian,
N. Farrow,
Daniel R. Albaugh,
Danielle Fowler,
R. Schneiderman,
E. Michael August,
...
Leslie Martin,
Melissa Hill-Drzewi,
S. Pullen,
Hidenori Takahashi,
S. De Lombaert
|
3 |
2011 |
3
🐜
|
