J. Higaki's Profile

Role	Title	Level	Year	L/R
🐜	Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors* 21 auth. D. Seiffert, Jodi Bradley, Cynthia M. Rominger, D. Rominger, Fude Yang, J. Meredith, Qian Wang, A. Roach, L. Thompson, S. Spitz, ... J. Higaki, S. Prakash, A. Combs, R. Copeland, S. Arneric, P. Hartig, D. W. Robertson, B. Cordell, A. Stern, R. Olson, R. Zaczek	7	2000	7 🐜
🐬	Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS T. Hagg, D. Quon, J. Higaki, S. Varon	7	1992	7 🐬
🦁	Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism J. Higaki, D. Quon, Z. Zhong, B. Cordell	7	1995	7 🦁
🦁	Engineered metalloregulation in enzymes. J. Higaki, R. Fletterick, C. Craik	6	1992	6 🦁
🐜	A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease. 15 auth. E. A. Mackay, Anne Ehrhard, M. Moniatte, C. Guenet, C. Tardif, C. Tarnus, O. Sorokine, B. Heintzelmann, Carole Nay, J. Rémy, ... J. Higaki, A. Dorsselaer, J. Wagner, C. Danzin, P. Mamont	6	1997	6 🐜
🦁	Regulation of serine protease activity by an engineered metal switch. J. Higaki, B. Haymore, S. Chen, R. Fletterick, C. Craik	6	1990	6 🦁
🐜	Secretion of beta-amyloid precursor protein involves multiple cleavage sites. 7 auth. Z. Zhong, J. Higaki, K. Murakami, Yu Wang, R. Catalano, D. Quon, ... B. Cordell	6	1994	6 🐜
🦁	Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin 14 auth. J. Higaki, A. Chakrabartty, Natalie J. Galant, K. Hadley, Bradley Hammerson, T. Nijjar, Ronald Torres, Jose R. Tapia, J. Salmans, R. Barbour, ... Stephen J. Tam, K. Flanagan, W. Zago, G. Kinney	6	2016	6 🦁
🐬	Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy. Natalie J. Galant, P. Westermark, J. Higaki, A. Chakrabartty	6	2017	6 🐬
🐬	An expression system for trypsin J. Vásquez, L. Evnin, J. Higaki, C. Craik	5	1989	5 🐬