|
🐜
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Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
13 auth.
C. Dugovic,
Jonathan E. Shelton,
L. Aluisio,
I. Fraser,
Xiaohui Jiang,
S. Sutton,
P. Bonaventure,
Sujin Yun,
Xiaorong Li,
B. Lord,
...
C. Dvorak,
N. Carruthers,
T. Lovenberg
|
7 |
2009 |
7
🐜
|
|
🐜
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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567
14 auth.
A. Bhattacharya,
Qi Wang,
Hong Ao,
J. Shoblock,
B. Lord,
L. Aluisio,
I. Fraser,
D. Nepomuceno,
R. Neff,
Natalie Welty,
...
T. Lovenberg,
P. Bonaventure,
A. Wickenden,
M. Letavic
|
7 |
2013 |
7
🐜
|
|
🐜
|
Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement
13 auth.
J. Shoblock,
Natalie Welty,
L. Aluisio,
I. Fraser,
S. T. Motley,
K. Morton,
J. Palmer,
P. Bonaventure,
N. Carruthers,
T. Lovenberg,
...
J. Boggs,
R. Galici,
R. Galici
|
7 |
2011 |
7
🐜
|
|
🐜
|
Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder
21 auth.
P. Bonaventure,
C. Dugovic,
M. Kramer,
P. de Boer,
Jaskaran Singh,
Sue J. Wilson,
K. Bertelsen,
J. Di,
Jonathan E. Shelton,
L. Aluisio,
...
Lisa K Dvorak,
I. Fraser,
B. Lord,
D. Nepomuceno,
A. Ahnaou,
W. Drinkenburg,
Wenying Chai,
C. Dvorak,
S. Sands,
N. Carruthers,
T. Lovenberg
|
6 |
2012 |
6
🐜
|
|
🐜
|
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
20 auth.
P. Bonaventure,
Jonathan E. Shelton,
Sujin Yun,
D. Nepomuceno,
S. Sutton,
L. Aluisio,
I. Fraser,
B. Lord,
J. Shoblock,
Natalie Welty,
...
S. Chaplan,
Z. Aguilar,
Robin Halter,
A. Ndifor,
T. Koudriakova,
M. Rizzolio,
M. Letavic,
N. Carruthers,
T. Lovenberg,
C. Dugovic
|
6 |
2015 |
6
🐜
|
|
🐜
|
Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia
14 auth.
A. Bhattacharya,
B. Lord,
J. Grigoleit,
Yingbo He,
I. Fraser,
Shannon N. Campbell,
Natalie Taylor,
L. Aluisio,
J. O'Connor,
M. Papp,
...
C. Chrovian,
N. Carruthers,
T. Lovenberg,
M. Letavic
|
5 |
2018 |
5
🐜
|
|
🐜
|
Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex
8 auth.
Wei Si,
L. Aluisio,
Naoe Okamura,
S. Clark,
I. Fraser,
Steven W. Sutton,
...
P. Bonaventure,
R. Reinscheid
|
5 |
2010 |
5
🐜
|
|
🐜
|
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
18 auth.
C. Chrovian,
Akinola Soyode-Johnson,
Alexander A Peterson,
Christine F. Gelin,
Xiaohu Deng,
C. Dvorak,
N. Carruthers,
B. Lord,
I. Fraser,
L. Aluisio,
...
K. Coe,
Brian P. Scott,
T. Koudriakova,
Freddy Schoetens,
Kia Sepassi,
D. Gallacher,
A. Bhattacharya,
M. Letavic
|
5 |
2018 |
5
🐜
|
|
🐜
|
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
26 auth.
M. Letavic,
B. Savall,
B. Allison,
L. Aluisio,
J. Andrés,
M. De Angelis,
Hong Ao,
Derek A. Beauchamp,
P. Bonaventure,
Stewart Bryant,
N. Carruthers,
M. Ceusters,
K. Coe,
C. Dvorak,
I. Fraser,
...
Christine F. Gelin,
T. Koudriakova,
Jimmy T. Liang,
B. Lord,
T. Lovenberg,
M. Otieno,
Freddy Schoetens,
Devin M. Swanson,
Qi Wang,
A. Wickenden,
A. Bhattacharya
|
5 |
2017 |
5
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|
