|
🐜
|
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
21 auth.
S. Hadano,
C. Hand,
H. Osuga,
Y. Yanagisawa,
A. Otomo,
R. S. Devon,
N. Miyamoto,
J. Showguchi-Miyata,
Yoshinori Okada,
R. Singaraja,
...
D. Figlewicz,
T. Kwiatkowski,
B. Hosler,
T. Sagie,
J. Skaug,
J. Nasir,
Robert H. Brown,
S. Scherer,
G. Rouleau,
M. Hayden,
J. Ikeda
|
9 |
2001 |
9
🐜
|
|
🐜
|
Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
11 auth.
Koki Fujimori,
Mitsuru Ishikawa,
A. Otomo,
N. Atsuta,
R. Nakamura,
T. Akiyama,
...
S. Hadano,
M. Aoki,
H. Saya,
G. Sobue,
H. Okano
|
8 |
2018 |
8
🐜
|
|
🦁
|
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.
15 auth.
A. Otomo,
S. Hadano,
Takeya Okada,
Hikaru Mizumura,
R. Kunita,
H. Nishijima,
J. Showguchi-Miyata,
Y. Yanagisawa,
Eri Kohiki,
Etsuko Suga,
...
M. Yasuda,
H. Osuga,
T. Nishimoto,
S. Narumiya,
J. Ikeda
|
8 |
2003 |
8
🦁
|
|
🐜
|
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.
13 auth.
S. Hadano,
Susanna C. Benn,
S. Kakuta,
A. Otomo,
K. Sudo,
R. Kunita,
K. Suzuki-Utsunomiya,
Hikaru Mizumura,
J. Shefner,
G. Cox,
...
Y. Iwakura,
Robert H. Brown,
J. Ikeda
|
7 |
2006 |
7
🐜
|
|
🐜
|
Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
10 auth.
S. Hadano,
A. Otomo,
R. Kunita,
K. Suzuki-Utsunomiya,
A. Akatsuka,
M. Koike,
...
M. Aoki,
Y. Uchiyama,
Y. Itoyama,
J. Ikeda
|
6 |
2010 |
6
🐜
|
|
🐬
|
The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis*
R. Kunita,
A. Otomo,
Hikaru Mizumura,
K. Suzuki-Utsunomiya,
S. Hadano,
J. Ikeda
|
6 |
2007 |
6
🐬
|
|
🐬
|
Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration
S. Hadano,
R. Kunita,
A. Otomo,
K. Suzuki-Utsunomiya,
J. Ikeda
|
6 |
2007 |
6
🐬
|
|
🐜
|
Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking*
8 auth.
R. Kunita,
A. Otomo,
Hikaru Mizumura,
Kyoko Suzuki,
J. Showguchi-Miyata,
Y. Yanagisawa,
...
S. Hadano,
J. Ikeda
|
5 |
2004 |
5
🐜
|
|
🦁
|
Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
A. Otomo,
Lei Pan,
S. Hadano
|
5 |
2012 |
5
🦁
|
|
🐜
|
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
19 auth.
S. Hadano,
Shun Mitsui,
Lei Pan,
A. Otomo,
M. Kubo,
Kai Sato,
S. Ono,
Wakana Onodera,
K. Abe,
Xueping Chen,
...
M. Koike,
Y. Uchiyama,
M. Aoki,
E. Warabi,
Masayuki Yamamoto,
T. Ishii,
T. Yanagawa,
H. Shang,
F. Yoshii
|
5 |
2016 |
5
🐜
|
