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🐜
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
26 auth.
L. Thompson,
Charity T. Aiken,
L. Kaltenbach,
N. Agrawal,
K. Illes,
A. Khoshnan,
Marta Martinez-Vincente,
M. Arrasate,
Jacqueline Gire O'Rourke,
Hasan Khashwji,
T. Lukácsovich,
Ya-zhen Zhu,
Alice L. Lau,
A. Massey,
Michael R. Hayden,
...
S. Zeitlin,
S. Finkbeiner,
K. Green,
F. LaFerla,
G. Bates,
Lan Huang,
P. Patterson,
D. Lo,
A. Cuervo,
J. Marsh,
J. Steffan
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8 |
2009 |
8
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|
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Potential function for the Huntingtin protein as a scaffold for selective autophagy
20 auth.
Joseph Ochaba,
T. Lukácsovich,
G. Csikós,
Shuqiu Zheng,
Julia Margulis,
Lisa Salazar,
Kai Mao,
Alice L. Lau,
Sylvia Y. Yeung,
S. Humbert,
...
F. Saudou,
D. Klionsky,
S. Finkbeiner,
S. Zeitlin,
J. Marsh,
D. Housman,
L. Thompson,
J. Steffan,
Diane E. Merry,
Albert R. La Spada
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8 |
2014 |
8
🐜
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|
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
51 auth.
Ryan G. Lim,
Lisa Salazar,
D. Wilton,
Alvin R. King,
Jennifer T. Stocksdale,
Delaram Sharifabad,
Alice L. Lau,
B. Stevens,
Jack C. Reidling,
S. Winokur,
M. Casale,
L. Thompson,
M. Pardo,
A. G. G. Díaz-Barriga,
M. Straccia,
...
Phil Sanders,
J. Alberch,
J. Canals,
J. Kaye,
Mariah Dunlap,
Lisa Jo,
H. May,
Elliot Mount,
Clifford Anderson-Bergman,
K. Haston,
S. Finkbeiner,
Amanda J. Kedaigle,
T. A. Gipson,
F. Yildirim,
C. Ng,
P. Milani,
D. Housman,
E. Fraenkel,
N. Allen,
P. Kemp,
R. S. Atwal,
M. Biagioli,
J. Gusella,
M. MacDonald,
S. Akimov,
N. Arbez,
Jacqueline C Stewart,
C. Ross,
Virginia B. Mattis,
Colton M. Tom,
L. Ornelas,
Anais Sahabian,
Lindsay Lenaeus,
B. Mandefro,
D. Sareen,
C. Svendsen
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7 |
2017 |
7
🐜
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|
🐜
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Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
21 auth.
Haiqun Jia,
J. Pallos,
V. Jacques,
Alice L. Lau,
Bin Tang,
Andrew Cooper,
A. Syed,
Judith M. Purcell,
Yi Chen,
Shefali Sharma,
...
Gavin R. Sangrey,
B. Shayna,
Darnell,
Heather L. Plasterer,
Ghazaleh Sadri‐Vakili,
J. Gottesfeld,
M. Leslie,
Thompson,
J. Rusche,
J. Marsh,
Elizabeth A. Thomas
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7 |
2012 |
7
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|
🐜
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Targeting H3K4 trimethylation in Huntington disease
20 auth.
Malini Vashishtha,
C. Ng,
F. Yildirim,
T. A. Gipson,
I. H. Kratter,
L. Bodai,
Wan-Doo Song,
Alice L. Lau,
Adam T. Labadorf,
Annie Vogel-Ciernia,
...
Juan C. Troncosco,
C. Ross,
G. Bates,
D. Krainc,
Ghazaleh Sadri‐Vakili,
S. Finkbeiner,
J. Marsh,
D. Housman,
E. Fraenkel,
L. Thompson
|
7 |
2013 |
7
🐜
|
|
🐜
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Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models
13 auth.
E. Sontag,
Gregor P Lotz,
N. Agrawal,
Andrew Tran,
Rebecca Aron,
Guocheng Yang,
Mihaela Necula,
Alice L. Lau,
S. Finkbeiner,
C. Glabe,
...
J. Marsh,
P. Muchowski,
L. Thompson
|
6 |
2012 |
6
🐜
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|
🐜
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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease
13 auth.
Xiaobei Zhao,
Xu-Qiao Chen,
E. Han,
Yue Hu,
Paul Paik,
Z. Ding,
J. Overman,
Alice L. Lau,
Sarah H. Shahmoradian,
W. Chiu,
...
L. Thompson,
Chengbiao Wu,
W. Mobley
|
6 |
2016 |
6
🐜
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|
🐜
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Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice
26 auth.
Jack C. Reidling,
A. Relaño-Ginés,
S. Holley,
Joseph Ochaba,
C. Moore,
Brian Fury,
Alice L. Lau,
Andrew Tran,
Sylvia Y. Yeung,
Delaram Salamati,
Chunni Zhu,
A. Hatami,
C. Cepeda,
Joshua Barry,
Talia Kamdjou,
...
Alvin R. King,
Dane Coleal-Bergum,
Nicholas R. Franich,
F. LaFerla,
J. Steffan,
M. Blurton-Jones,
C. Meshul,
G. Bauer,
M. Levine,
M. Chesselet,
L. Thompson
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6 |
2017 |
6
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|
🐜
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Decreases in protease nexins in Alzheimer's disease brain
7 auth.
B. H. Choi,
R. Kim,
P. Vaughan,
Alice L. Lau,
W. E. Nostrand,
C. Cotman,
...
D. Cunningham
|
5 |
1995 |
5
🐜
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|
🐜
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Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
15 auth.
I. H. Kratter,
I. H. Kratter,
Hengameh Zahed,
Alice L. Lau,
Andrey S. Tsvetkov,
Aaron Daub,
Kurt F. Weiberth,
X. Gu,
F. Saudou,
S. Humbert,
...
X. W. Yang,
A. Osmand,
J. Steffan,
E. Masliah,
S. Finkbeiner
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5 |
2016 |
5
🐜
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