|
π
|
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
22 auth.
Rebecca C. Coll,
A. Robertson,
J. Chae,
Sarah C. Higgins,
RauΜl MunΜoz-Planillo,
Marco C. Inserra,
I. Vetter,
Lara S. Dungan,
Brian G. Monks,
A. Stutz,
...
Daniel E. Croker,
M. Butler,
M. Haneklaus,
Caroline E. Sutton,
G. NΓΊΓ±ez,
E. Latz,
D. Kastner,
K. Mills,
S. Masters,
K. Schroder,
M. Cooper,
L. OβNeill
|
11 |
2015 |
11
π
|
|
π
|
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
28 auth.
A. Begovich,
V. Carlton,
L. Honigberg,
Steven J. Schrodi,
A. Chokkalingam,
H. Alexander,
K. Ardlie,
Qiqing Huang,
Ashley M. Smith,
J. Spoerke,
Marion T. Conn,
Monica Chang,
Sheng-Yung P. Chang,
R. Saiki,
J. Catanese,
...
Diane U. Leong,
Veronica E. Garcia,
L. McAllister,
D. Jeffery,
Annette Lee,
F. Batliwalla,
E. Remmers,
L. Criswell,
M. Seldin,
D. Kastner,
C. Amos,
J. Sninsky,
P. Gregersen
|
10 |
2004 |
10
π
|
|
π
|
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
68 auth.
E. Stahl,
S. Raychaudhuri,
E. Remmers,
G. Xie,
S. Eyre,
Brian Thomson,
Yonghong Li,
F. Kurreeman,
A. Zhernakova,
A. Hinks,
C. Guiducci,
Robert Chen,
L. Alfredsson,
C. Amos,
K. Ardlie,
...
A. Barton,
J. Bowes,
E. Brouwer,
N. Burtt,
J. Catanese,
J. Coblyn,
M. Coenen,
K. Costenbader,
L. Criswell,
J. Crusius,
J. Cui,
P. D. Bakker,
P. D. Jager,
B. Ding,
P. Emery,
E. Flynn,
Pille Harrison,
L. Hocking,
T. Huizinga,
D. Kastner,
X. Ke,
Annette Lee,
Xiangdong Liu,
Paul Martin,
A. Morgan,
L. Padyukov,
M. Posthumus,
T. Radstake,
D. Reid,
Mark Seielstad,
M. Seldin,
N. Shadick,
S. Steer,
P. Tak,
W. Thomson,
A. Mil,
I. Horst-Bruinsma,
C. E. Schoot,
P. Riel,
M. Weinblatt,
A. Wilson,
G. Wolbink,
Bryan Paul Wordsworth,
C. Wijmenga,
E. Karlson,
R. Toes,
N. Vries,
A. Begovich,
Jane Worthington,
K. Siminovitch,
P. Gregersen,
L. Klareskog,
R. Plenge
|
10 |
2010 |
10
π
|
|
π’
|
Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes
33 auth.
M. McDermott,
I. Aksentijevich,
J. Galon,
E. McDermott,
B. Ogunkolade,
M. Centola,
E. Mansfield,
M. Gadina,
L. Karenko,
T. Pettersson,
J. McCarthy,
D. M. Frucht,
M. Aringer,
Yelizaveta Torosyan,
A. Teppo,
...
Meredith Wilson,
H. Karaarslan,
Y. Wan,
I. Todd,
G. Wood,
R. Schlimgen,
T. R. Kumarajeewa,
S. Cooper,
J. Vella,
C. Amos,
J. Mulley,
K. Quane,
M. Molloy,
A. Ranki,
R. Powell,
G. Hitman,
J. OβShea,
D. Kastner
|
10 |
1999 |
10
π’
|
|
π’
|
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*).
S. Masters,
A. Simon,
I. Aksentijevich,
D. Kastner
|
10 |
2009 |
10
π’
|
|
π
|
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
23 auth.
E. Remmers,
R. Plenge,
Annette Lee,
R. Graham,
Geoffrey Hom,
T. Behrens,
P. D. de Bakker,
J. Le,
Hye-Soon Lee,
F. Batliwalla,
...
Wentian Li,
S. Masters,
M. Booty,
J. Carulli,
L. Padyukov,
L. Alfredsson,
L. Klareskog,
W. Chen,
C. Amos,
L. Criswell,
M. Seldin,
D. Kastner,
P. Gregersen
|
10 |
2007 |
10
π
|
|
π
|
Activated STING in a vascular and pulmonary syndrome.
64 auth.
Yin Liu,
A. A. Jesus,
B. Marrero,
Dan Yang,
S. Ramsey,
S. Ramsey,
G. Sanchez,
K. Tenbrock,
K. Tenbrock,
H. Wittkowski,
H. Wittkowski,
O. Jones,
O. Jones,
H. Kuehn,
C. Lee,
...
M. Dimattia,
E. Cowen,
B. Gonzalez,
Ira W. Palmer,
J. DiGiovanna,
A. Biancotto,
Ha Won Kim,
W. Tsai,
A. Trier,
Yan Huang,
D. Stone,
S. Hill,
H. J. Kim,
C. S. Hilaire,
S. Gurprasad,
N. Plass,
D. Chapelle,
I. HorkayneβSzakaly,
I. HorkayneβSzakaly,
D. Foell,
D. Foell,
A. Barysenka,
A. Barysenka,
F. Candotti,
S. Holland,
J. Hughes,
J. Hughes,
H. Mehmet,
H. Mehmet,
A. Issekutz,
A. Issekutz,
M. Raffeld,
J. McElwee,
J. McElwee,
J. Fontana,
C. Minniti,
S. Moir,
D. Kastner,
M. Gadina,
A. Steven,
P. Wingfield,
S. Brooks,
S. Rosenzweig,
T. Fleisher,
Z. Deng,
M. Boehm,
A. Paller,
A. Paller,
R. Goldbach-Mansky
|
10 |
2014 |
10
π
|
|
π
|
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
9 auth.
Geun-Shik Lee,
N. Subramanian,
A. I. Kim,
I. Aksentijevich,
R. Goldbach-Mansky,
D. Sacks,
...
R. Germain,
D. Kastner,
J. Chae
|
9 |
2012 |
9
π
|
|
π
|
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
9 auth.
Ariel C. Bulua,
A. Simon,
R. Maddipati,
M. Pelletier,
Heiyoung Park,
Kye-Young Kim,
...
M. Sack,
D. Kastner,
R. Siegel
|
9 |
2011 |
9
π
|
|
π’
|
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition.
40 auth.
R. Goldbach-Mansky,
Natalie J. M. Dailey,
S. Canna,
A. Gelabert,
Janet Jones,
B. Rubin,
H. Kim,
C. Brewer,
C. Zalewski,
E. Wiggs,
S. Hill,
M. Turner,
B. Karp,
I. Aksentijevich,
F. Pucino,
...
S. Penzak,
M. Haverkamp,
L. Stein,
B. Adams,
T. Moore,
R. Fuhlbrigge,
B. Shaham,
J. Jarvis,
K. Oβneil,
R. Vehe,
L. Beitz,
G. Gardner,
W. Hannan,
R. Warren,
W. Horn,
J. Cole,
S. Paul,
P. Hawkins,
Tuyet-Hang Pham,
Christopher Snyder,
R. Wesley,
S. Hoffmann,
S. Holland,
J. Butman,
D. Kastner
|
9 |
2006 |
9
π’
|
|
π
|
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
29 auth.
R. Plenge,
Mark Seielstad,
L. Padyukov,
Annette Lee,
E. Remmers,
B. Ding,
A. Liew,
H. Khalili,
A. Chandrasekaran,
Leela R. L. Davies,
Wentian Li,
Adrian Tan,
C. Bonnard,
R. T. Ong,
A. Thalamuthu,
...
S. Pettersson,
Chunyu Liu,
C. Tian,
W. Chen,
J. Carulli,
Evan Beckman,
D. Altshuler,
L. Alfredsson,
L. Criswell,
C. Amos,
M. Seldin,
D. Kastner,
L. Klareskog,
P. Gregersen
|
9 |
2007 |
9
π
|
|
π
|
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
31 auth.
I. Aksentijevich,
M. Nowak,
Mustapha Mallah,
J. Chae,
W. Watford,
S. Hofmann,
L. Stein,
R. Russo,
D. Goldsmith,
P. Dent,
H. Rosenberg,
Frances Austin,
E. Remmers,
J. Balow,
S. Rosenzweig,
...
Hirsh D. Komarow,
N. Shoham,
G. Wood,
Janet Jones,
Nadira Mangra,
H. Carrero,
B. Adams,
T. Moore,
K. Schikler,
H. Hoffman,
D. Lovell,
R. Lipnick,
K. Barron,
J. OβShea,
D. Kastner,
R. Goldbach-Mansky
|
9 |
2002 |
9
π
|
|
π
|
Early-onset stroke and vasculopathy associated with mutations in ADA2.
64 auth.
Qing Zhou,
Dan Yang,
A. Ombrello,
A. Zavialov,
C. Toro,
A. Zavialov,
D. Stone,
J. Chae,
S. Rosenzweig,
Kevin Bishop,
K. Barron,
H. Kuehn,
P. Hoffmann,
A. Negro,
W. Tsai,
...
E. Cowen,
W. Pei,
J. Milner,
Christopher Silvin,
T. Heller,
D. Chin,
N. Patronas,
J. Barber,
C. Lee,
G. Wood,
A. Ling,
S. Kelly,
D. Kleiner,
J. Mullikin,
N. Ganson,
H. Kong,
S. Hambleton,
F. Candotti,
M. Quezado,
K. Calvo,
H. Alao,
B. Barham,
Anne Jones,
J. Meschia,
B. Worrall,
S. Kasner,
S. Rich,
R. Goldbach-Mansky,
M. Abinun,
E. Chalom,
A. Gotte,
M. Punaro,
V. Pascual,
J. Verbsky,
T. Torgerson,
N. Singer,
T. Gershon,
S. Ozen,
O. Karadag,
T. Fleisher,
E. Remmers,
S. Burgess,
S. Moir,
M. Gadina,
R. Sood,
M. Hershfield,
M. Boehm,
D. Kastner,
I. Aksentijevich
|
9 |
2014 |
9
π
|
