|
🐜
|
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
25 auth.
C. Marchetti,
B. Swartzwelter,
F. Gamboni,
C. Neff,
K. Richter,
T. Azam,
S. Carta,
Isak W. Tengesdal,
T. Nemkov,
A. D’Alessandro,
C. Henry,
Gerald S. Jones,
Scott A Goodrich,
J. P. St Laurent,
T. Jones,
...
C. Scribner,
R. Barrow,
R. Altman,
D. Skouras,
M. Gattorno,
V. Grau,
S. Janciauskiene,
A. Rubartelli,
L. Joosten,
C. Dinarello
|
8 |
2018 |
8
🐜
|
|
🐜
|
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease
8 auth.
N. Lonnemann,
Shirin Hosseini,
C. Marchetti,
D. Skouras,
D. Stefanoni,
A. D’Alessandro,
...
C. Dinarello,
M. Korte
|
7 |
2020 |
7
🐜
|
|
🐜
|
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
13 auth.
V. Klück,
T. Jansen,
M. Janssen,
A. Comarniceanu,
M. Efde,
Isak W. Tengesdal,
K. Schraa,
M. C. Cleophas,
C. Scribner,
D. Skouras,
...
C. Marchetti,
C. Dinarello,
L. Joosten
|
7 |
2020 |
7
🐜
|
|
🐬
|
OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
Alba Sánchez-Fernández,
D. Skouras,
C. Dinarello,
Rubèn López-Vales
|
6 |
2019 |
6
🐬
|
|
🐬
|
The NLRP3 inflammasome inhibitor, OLT1177®, ameliorates experimental allergic asthma in mice
L. Lunding,
D. Skouras,
C. Vock,
C. Dinarello,
M. Wegmann
|
4 |
2021 |
4
🐬
|
|
🐜
|
Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury
7 auth.
Jesús Amo-Aparicio,
Joana Garcia-Garcia,
María Puigdomenech,
Isaac Francos-Quijorna,
D. Skouras,
C. Dinarello,
...
Rubèn López-Vales
|
4 |
2021 |
4
🐜
|
|
🐜
|
AB1247 RATIONALE AND DESIGN FOR PODAGRA II: A MULTICENTER RANDOMIZED PHASE 2/3 STUDY ASSESSING THE EFFICACY AND SAFETY OF DAPANSUTRILE, AN ORALLY ADMINISTERED SPECIFIC INHIBITOR OF THE NLRP3 INFLAMMASOME IN SUBJECTS WITH AN ACUTE GOUT FLARE
11 auth.
T. Jansen,
P. Piscitelli,
C. Barrow,
K. Vought,
A. Poshusta,
H. Kapushoc,
...
A. Leonard-Segal,
M. Noor,
D. Skouras,
C. Dinarello,
N. Schlesinger
|
0 |
2023 |
0
🐜
|
