|
π
|
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
30 auth.
J. P. Clancy,
Steven M. Rowe,
F. Accurso,
Moira L. Aitken,
Raouf S Amin,
M. Ashlock,
M. Ballmann,
Michael P. Boyle,
I. Bronsveld,
Preston W Campbell,
K. De Boeck,
Scott H Donaldson,
Henry L. Dorkin,
J. M. Dunitz,
Peter R Durie,
...
M. Jain,
A. Leonard,
Karen S. McCoy,
Richard B. Moss,
Joseph M. Pilewski,
D. Rosenbluth,
Ronald C. Rubenstein,
M. Schechter,
M. Botfield,
C. OrdonΜez,
George T Spencer-Green,
L. Vernillet,
S. Wisseh,
Karl Yen,
M. Konstan
|
9 |
2011 |
9
π
|
|
π¬
|
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
J. Ladbury,
M. Lemmon,
Min Zhou,
Jeremy Green,
M. Botfield,
J. Schlessinger
|
7 |
1995 |
7
π¬
|
|
π¬
|
Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling*
E. Ottinger,
M. Botfield,
S. Shoelson
|
7 |
1998 |
7
π¬
|
|
π¬
|
Phage display selection of ligand residues important for Src homology 3 domain binding specificity.
R. Rickles,
M. Botfield,
X. M. Zhou,
P. Henry,
J. Brugge,
M. Zoller
|
7 |
1995 |
7
π¬
|
|
π¬
|
SH3 domains and drug design: ligands, structure, and biological function.
D. Dalgarno,
M. Botfield,
R. Rickles
|
7 |
1997 |
7
π¬
|
|
π’
|
1369 TELAPREVIR SUBSTANTIALLY IMPROVED SVR RATES ACROSS ALL IL28B GENOTYPES IN THE ADVANCE TRIAL
13 auth.
I. Jacobson,
I. Catlett,
P. Marcellin,
N. Bzowej,
A. Muir,
N. Adda,
L. Bengtsson,
S. George,
S. Seepersaud,
Ravi Ramachandran,
...
K. Sussky,
R. Kauffman,
M. Botfield
|
6 |
2011 |
6
π’
|
|
π
|
Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.
14 auth.
C. Vu,
E. Corpuz,
T. Merry,
S. Pradeepan,
C. Bartlett,
R. Bohacek,
M. Botfield,
C. Eyermann,
B. Lynch,
I. Macneil,
...
M. Ram,
M. V. van Schravendijk,
S. Violette,
T. Sawyer
|
6 |
1999 |
6
π
|
|
π
|
Active-Site Residues of Escherichia coli DNA Gyrase Required in Coupling ATP Hydrolysis to DNA Supercoiling and Amino Acid Substitutions Leading to Novobiocin Resistance
11 auth.
C. H. Gross,
J. Parsons,
T. Grossman,
P. Charifson,
S. Bellon,
James Jernee,
...
Maureen D. Dwyer,
S. P. Chambers,
W. Markland,
M. Botfield,
S. Raybuck
|
6 |
2003 |
6
π
|
|
π¦
|
Mutations that simultaneously alter both sugar and cation specificity in the melibiose carrier of Escherichia coli.
M. Botfield,
T. Wilson
|
6 |
1988 |
6
π¦
|
|
π
|
Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis.
9 auth.
T. Altes,
Mac Johnson,
M. Fidler,
M. Botfield,
N. Tustison,
C. Leiva-Salinas,
...
E. D. de Lange,
D. Froh,
J. Mugler
|
6 |
2017 |
6
π
|
