|
🐜
|
Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial.
21 auth.
A. Zhu,
R. Finn,
J. Edeline,
S. Cattan,
S. Ogasawara,
D. Palmer,
C. Verslype,
V. Zagonel,
L. Fartoux,
A. Vogel,
...
D. Sarker,
G. Verset,
S. Chan,
J. Knox,
B. Daniele,
A. Webber,
S. Ebbinghaus,
Junshui Ma,
A. Siegel,
A. Cheng,
M. Kudo
|
10 |
2018 |
10
🐜
|
|
🦁
|
Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer
D. Sarker,
A. Reid,
T. Yap,
J. D. de Bono
|
8 |
2009 |
8
🦁
|
|
🦁
|
First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors
22 auth.
D. Sarker,
J. Ang,
R. Baird,
R. Kristeleit,
K. Shah,
V. Moreno,
P. Clarke,
F. Raynaud,
G. Levy,
J. Ware,
...
K. Mazina,
R. Lin,
J. Wu,
J. Fredrickson,
J. Spoerke,
M. Lackner,
Yibing Yan,
L. Friedman,
S. Kaye,
M. Derynck,
P. Workman,
J. D. de Bono
|
8 |
2014 |
8
🦁
|
|
🐜
|
The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer
16 auth.
U. Banerji,
D. Camidge,
H. Verheul,
R. Agarwal,
D. Sarker,
S. Kaye,
I. Desar,
J. Timmer-Bonte,
S. Eckhardt,
K. Lewis,
...
K. Brown,
M. Cantarini,
C. Morris,
Sarah M. A. George,
Paul D. Smith,
C. V. van Herpen
|
7 |
2010 |
7
🐜
|
|
🐜
|
Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours
16 auth.
N. Turner,
S. Strauss,
D. Sarker,
R. Gillmore,
A. Kirkwood,
A. Hackshaw,
A. Papadopoulou,
Jimmy D. Bell,
I. Kayani,
C. Toumpanakis,
...
Federica Grillo,
A. Mayer,
D. Hochhauser,
R. Begent,
M. Caplin,
T. Meyer
|
7 |
2010 |
7
🐜
|
|
🐜
|
Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study.
25 auth.
V. Subbiah,
Mimi I Hu,
L. Wirth,
M. Schuler,
A. Mansfield,
G. Curigliano,
M. Brose,
V. Zhu,
S. Leboulleux,
D. Bowles,
C. Baik,
D. Adkins,
B. Keam,
I. Matos,
E. Garralda,
...
J. Gainor,
G. Lopes,
Chia‐Chi Lin,
Y. Godbert,
D. Sarker,
Stephen G. Miller,
C. Clifford,
Hui Zhang,
C. Turner,
Matthew H. Taylor
|
7 |
2021 |
7
🐜
|
|
🐜
|
Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma
32 auth.
G. Abou-Alfa,
G. Abou-Alfa,
S. Qin,
B. Ryoo,
Sheng-Nan Lu,
Sheng-Nan Lu,
C. Yen,
Yin-Hsun Feng,
Ho Yeong Lim,
F. Izzo,
M. Colombo,
D. Sarker,
L. Bolondi,
G. Vaccaro,
W. Harris,
...
Z. Chen,
R. Hubner,
T. Meyer,
Weijing Sun,
J. Harding,
J. Harding,
E. Hollywood,
Jennifer Ma,
P. Wan,
M. Ly,
J. Bomalaski,
A. Johnston,
Chia‐Chi Lin,
Y. Chao,
L.-T. Chen,
L.-T. Chen,
L.-T. Chen
|
7 |
2018 |
7
🐜
|
|
🐜
|
Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer
21 auth.
H. Kocher,
B. Basu,
F. Froeling,
D. Sarker,
S. Slater,
D. Carlin,
N. deSouza,
K. D. De Paepe,
M. Goulart,
C. Hughes,
...
A. Imrali,
R. Roberts,
M. Pawula,
Richard Houghton,
C. Lawrence,
Y. Yogeswaran,
K. Mousa,
C. Coetzee,
P. Sasieni,
Aaron Prendergast,
D. Propper
|
7 |
2020 |
7
🐜
|
|
🦁
|
Pharmacodynamic biomarkers for molecular cancer therapeutics.
D. Sarker,
P. Workman
|
7 |
2007 |
7
🦁
|
|
🦁
|
A Phase I Pharmacokinetic and Pharmacodynamic Study of TKI258, an Oral, Multitargeted Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors
18 auth.
D. Sarker,
R. Molife,
T. Evans,
M. Hardie,
C. Marriott,
Priska Butzberger-Zimmerli,
R. Morrison,
J. Fox,
C. Heise,
S. Louie,
...
N. Aziz,
F. Garzon,
G. Michelson,
I. Judson,
D. Jadayel,
E. Braendle,
J. D. de Bono,
De Bono
|
7 |
2008 |
7
🦁
|
|
🐜
|
PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.
40 auth.
P. Ghaneh,
R. Hanson,
A. Titman,
G. Lancaster,
C. Plumpton,
H. Lloyd-Williams,
S. T. Yeo,
R. Edwards,
Colin D. Johnson,
M. Abu Hilal,
A. Higginson,
T. Armstrong,
A. Smith,
A. Scarsbrook,
C. McKay,
...
R. Carter,
R. Sutcliffe,
S. Bramhall,
H. Kocher,
D. Cunningham,
S. Pereira,
B. Davidson,
D. Chang,
Saboor Khan,
I. Zealley,
D. Sarker,
Bilal Al Sarireh,
R. Charnley,
D. Lobo,
M. Nicolson,
C. Halloran,
M. Raraty,
R. Sutton,
S. Vinjamuri,
Jonathan E Evans,
F. Campbell,
J. Deeks,
B. Sanghera,
W. Wong,
J. Neoptolemos
|
6 |
2018 |
6
🐜
|
