| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
|
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
18 auth. Catherine Tan, J. Kuchroo, P. Sage, D. Liang, Loise M. Francisco, Jessica Buck, Y. R. Thaker, Qianxia Zhang, Shannon L. McArdel, Vikram R. Juneja, ...
Tan et al. provide novel insights into understanding how PD-1 regulates regulatory T (T reg) cells. More specifically, this study demonstrates that loss of PD-1 on T reg cells leads to enhanced T reg cell suppressor function in vitro and in vivo. Th…
Tan et al. provide novel insights into understanding how PD-1 regulates regulatory T (T reg) cells. More specifically, this study demonstrates that loss of PD-1 on T reg cells leads to enhanced T reg cell suppressor function in vitro and in vivo. These findings have clinical relevance for understanding the efficacy of PD-1– and PD-L1–mediated checkpoint blockade.
Published in
Journal of Experimental Medicine
|
32
|
7 | 2020 |
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