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Water amino acid chelated trace mineral-supplementation decreases circulating and intestinal HSP70 and pro-inflammatory cytokine gene expression in heat-stressed broiler chickens.
M. Baxter, E. Greene, M. Kidd, G. Téllez-Isaías, S. Orlowski, S. Dridi
Heat stress (HS) is a financial and physiological burden on the poultry industry and the mitigation of the adverse effects of HS is vital to poultry production sustainability. The purpose of this study was, therefore, to determine the effects of an …
Heat stress (HS) is a financial and physiological burden on the poultry industry and the mitigation of the adverse effects of HS is vital to poultry production sustainability. The purpose of this study was, therefore, to determine the effects of an amino acid chelated trace mineral supplement on growth performance, stress and inflammatory markers, and meat quality in heat-stressed broilers. One day-old Cobb 500 male broilers (n=480) were allocated into twelve environmental chambers (24 floor pens) and divided into two groups: one group supplemented with amino acid chelated trace mineral in drinking water and one control group. On d28, birds were subjected to chronic heat stress (HS, 2 weeks, 35°C and 20-30% RH) or maintained at thermoneutral condition (TN, 24°C) in a 2x2 factorial design. Feed intake, water consumption, and body weight were recorded. At d42, serum Fluorescein Isothiocyanate dextran (FITC-D), and blood gas, electrolyte, and stress markers were measured. Jejunum samples were collected to measure gene expression of stress, inflammation, and tight junction proteins. The rest of birds were processed to evaluate carcass traits. HS resulted in an increase in core body temperature, which increased water intake and decreased feed intake, body weight, and feed efficiency (P<0.05). HS reduced carcass yield and the weight of all parts (P<0.05). HS significantly increased levels of circulating corticosterone, heat shock protein 70 (HSP70), interleukin 18 (IL-18), tumor necrosis factor alpha (TNFα), C-reactive protein (CRP), and nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain containing 3 (NLRP3) expression. HS significantly increased serum FITC-D levels and the expression of HSP70 and IL-18 in the jejunum. Although it did not affect growth performance, amino acid chelated trace mineral supplementation reversed the effect of HS by reducing corticosterone and FITC-D levels and the expression of stress and pro-inflammatory cytokines in the circulation and the jejunum. However, it upregulated these parameters in birds maintained under TN conditions. Together, these data indicate that the amino acid chelated trace mineral might alleviate stress and inflammation and improve gut integrity in heat-stressed but not thermoneutral broilers.
Published in Journal of Animal Science
1
 5 2020