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🐜
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SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
22 auth.
B. Malcolm,
Rong Liu,
F. Lahser,
S. Agrawal,
B. Belanger,
N. Butkiewicz,
R. Chase,
F. Gheyas,
A. Hart,
D. Hesk,
...
P. Ingravallo,
C. Jiang,
R. Kong,
J. Lu,
J. Pichardo,
A. Prongay,
A. Skelton,
X. Tong,
S. Venkatraman,
E. Xia,
V. Girijavallabhan,
F. Njoroge
|
8 |
2006 |
8
🐜
|
|
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Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:
52 auth.
S. Venkatraman,
S. Bogen,
A. Arasappan,
F. Bennett,
Kevin X. Chen,
E. Jao,
Yi-Tsung Liu,
R. Lovey,
S. Hendrata,
Yuhua Huang,
W. Pan,
T. Parekh,
P. Pinto,
V. Popov,
R. Pike,
...
S. Ruan,
B. Santhanam,
B. Vibulbhan,
Wanli Wu,
Weiying Yang,
Jian-she Kong,
Xiang Liang,
J. Wong,
Rong Liu,
N. Butkiewicz,
R. Chase,
A. Hart,
S. Agrawal,
P. Ingravallo,
J. Pichardo,
R. Kong,
B. Baroudy,
B. Malcolm,
Zhuyan Guo,
A. Prongay,
V. Madison,
L. Broske,
Xiaoming Cui,
K. Cheng,
Yunsheng Hsieh,
J. Brisson,
D. Prelusky,
Walter A. Korfmacher,
Ronald E. White,
S. Bogdanowich-Knipp‡,
A. Pavlovsky,
P. Bradley,
A. Saksena,
A. Ganguly,
J. Piwinski,
V. Girijavallabhan,
F. Njoroge
|
7 |
2006 |
7
🐜
|
|
🐜
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Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
29 auth.
S. Bogen,
A. Arasappan,
F. Bennett,
Kevin X. Chen,
E. Jao,
Yi-Tsung Liu,
R. Lovey,
S. Venkatraman,
W. Pan,
T. Parekh,
R. Pike,
S. Ruan,
Rong Liu,
B. Baroudy,
S. Agrawal,
...
R. Chase,
P. Ingravallo,
J. Pichardo,
A. Prongay,
J. Brisson,
Tony Y. Hsieh,
K. Cheng,
Scott J. Kemp,
Odile E. Levy,
M. Lim-Wilby,
Susan Y. Tamura,
A. Saksena,
V. Girijavallabhan,
F. Njoroge
|
5 |
2006 |
5
🐜
|
|
🐜
|
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
18 auth.
S. Venkatraman,
F. Velázquez,
Wanli Wu,
Melissa L. Blackman,
Kevin X. Chen,
S. Bogen,
L. Nair,
X. Tong,
R. Chase,
A. Hart,
...
S. Agrawal,
J. Pichardo,
A. Prongay,
K. Cheng,
V. Girijavallabhan,
J. Piwinski,
N. Shih,
F. Njoroge
|
5 |
2009 |
5
🐜
|
|
🐜
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I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
32 auth.
G. Anilkumar,
C. Lesburg,
O. Selyutin,
S. Rosenblum,
Qingbei Zeng,
Yueheng Jiang,
T. Chan,
H. Pu,
H. Vaccaro,
Li Wang,
F. Bennett,
Kevin X. Chen,
J. Duca,
Stephen Gavalas,
Yuhua Huang,
...
P. Pinto,
M. Sannigrahi,
F. Velázquez,
S. Venkatraman,
B. Vibulbhan,
S. Agrawal,
N. Butkiewicz,
B. Feld,
E. Ferrari,
Zhiqing He,
Chuan-kui Jiang,
R. Palermo,
Patricia McMonagle,
H.‐C. Huang,
N. Shih,
George F. Njoroge,
J. Kozlowski
|
5 |
2011 |
5
🐜
|
|
🐜
|
Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.
32 auth.
Ling Tong,
Wensheng Yu,
Lei Chen,
O. Selyutin,
M. Dwyer,
Anilkumar G. Nair,
R. Mazzola,
Jae‐Hun Kim,
D. Sha,
Jingjun Yin,
Rebecca T. Ruck,
I. Davies,
Bin Hu,
B. Zhong,
Jinglai Hao,
...
Tao Ji,
Shuai Zan,
Rong Liu,
S. Agrawal,
E. Xia,
S. Curry,
Patricia McMonagle,
Karin Bystol,
F. Lahser,
D. Carr,
Laura R Rokosz,
P. Ingravallo,
Shiying Chen,
Kung-I Feng,
M. Cartwright,
E. Asante-Appiah,
J. Kozlowski
|
5 |
2017 |
5
🐜
|
|
🐜
|
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4 Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
42 auth.
Ling Tong,
Wenping Li,
M. M. Lo,
Xiaolei Gao,
J. Wai,
M. Rudd,
D. Tellers,
A. Joshi,
Z. Zeng,
Patricia Miller,
C. Salinas,
K. Riffel,
Hyking Haley,
Mona Purcell,
M. Holahan,
...
L. Gantert,
Jeffrey W. Schubert,
Kristen Jones,
James Mulhearn,
M. Egbertson,
Z. Meng,
B. Hanney,
R. Gomez,
Scott T. Harrison,
P. Mcquade,
T. Bueters,
J. Uslaner,
J. Morrow,
F. Thomson,
J. Kong,
Jing Liao,
O. Selyutin,
Jianming Bao,
N. Hastings,
S. Agrawal,
Brian C. Magliaro,
F. Monsma,
Michelle D. Smith,
Stefania Risso,
D. Hesk,
E. Hostetler,
R. Mazzola
|
5 |
2020 |
5
🐜
|
|
🐜
|
Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
27 auth.
Kevin X. Chen,
B. Vibulbhan,
Weiying Yang,
M. Sannigrahi,
F. Velázquez,
T. Chan,
S. Venkatraman,
G. Anilkumar,
Qingbei Zeng,
F. Bennet,
Yueheng Jiang,
C. Lesburg,
J. Duca,
P. Pinto,
Stephen Gavalas,
...
Yuhua Huang,
Wanli Wu,
O. Selyutin,
S. Agrawal,
B. Feld,
Hsueh‐Cheng Huang,
Cheng Li,
K. Cheng,
N. Shih,
J. Kozlowski,
S. Rosenblum,
F. Njoroge
|
4 |
2012 |
4
🐜
|
|
🐜
|
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.
38 auth.
S. Neelamkavil,
S. Agrawal,
T. Bara,
C. Bennett,
Sathesh Bhat,
Dipshikha Biswas,
L. Brockunier,
Nicole Buist,
Duane Burnette,
M. Cartwright,
S. Chackalamannil,
R. Chase,
Mariappan Chelliah,
Austin Chen,
Martin C. Clasby,
...
V. J. Colandrea,
I. Davies,
K. Eagen,
Zhuyan Guo,
Yongxin Han,
J. Howe,
Charles L. Jayne,
H. Josien,
S. Kargman,
Karen M Marcantonio,
S. Miao,
Randy R Miller,
Andrew F Nolting,
P. Pinto,
M. Rajagopalan,
Rebecca T. Ruck,
Unmesh G. Shah,
A. Soriano,
D. Sperbeck,
F. Velázquez,
Jin Wu,
Yan Xia,
S. Venkatraman
|
4 |
2016 |
4
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|
