| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
|
IgG Binding Sites on Human FCγ Receptors
A. Tamm, R. Schmidt
The structure for the three human Fcγ receptors classes FCγRI (CD64), FCγRII (CD32) and FCγRIII (CD16) has been well characterized. Here the IgG binding sites on FCγRII and FCγRIII with their responsive FG, BC and C'/E loops on the membrane proximal…
The structure for the three human Fcγ receptors classes FCγRI (CD64), FCγRII (CD32) and FCγRIII (CD16) has been well characterized. Here the IgG binding sites on FCγRII and FCγRIII with their responsive FG, BC and C'/E loops on the membrane proximal domains are described in detail. For FCγRI the second extracellular domain is suggested as a key structure of IgG binding. The lower hinge regions of human and murine IgG binding to these Fc receptors and their structural relationship in FcγR-IgG interactions are discussed. The potential of inhibiting the pathophysiological effects of Fcγ receptors by blocking studies are considered for future therapeutic modalities.
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7
|
5 | 1997 |
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