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OP0020 Validation of new systemic lupus erythematosus classification criteria
51 auth. M. Aringer, K. Costenbader, R. Brinks, D. Boumpas, D. Daikh, D. Jayne, D. Kamen, M. Mosca, R. Ramsey‐Goldman, J. Smolen, D. Wofsy, B. Diamond, S. Jacobsen, W. McCune, G. Ruiz-Irastorza, ...
Background This 4 phase project1 jointly supported by EULAR and ACR has led to draft criteria.2 Objectives To simplify and validate the new criteria in a large international cohort. Methods 23 expert centres each contributed up to 100 patients with …
Background This 4 phase project1 jointly supported by EULAR and ACR has led to draft criteria.2 Objectives To simplify and validate the new criteria in a large international cohort. Methods 23 expert centres each contributed up to 100 patients with SLE and with non-SLE diagnoses. Diagnoses were verified by 3 independent reviewers for 1,193 SLE and 1059 non-SLE patients. 500 randomly selected SLE and non-SLE patients formed the derivation cohort and the remainder the validation cohort. Results The criteria were fine-tuned and simplified, using ANA of ≥1:80 as entry criterion and a classification threshold of 10. Renal Class III/IV nephritis 10 Class II/V nephritis 8 Proteinuria≥0.5 g/day 4 Specific antibodies Anti-Sm orAnti-dsDNA 6 Muco-cutaneous ACLE 6 SCLE orDLE 4 Alopecia or oral ulcers 2 Serosa Acute pericarditis 6 Effusion 5 Musculo-skeletal Arthritis 6 CNS Seizures 5 Psychosis 3 Delirium 2 Blood Autoimmune hemolysis or thrombocytopenia 4 Leukopenia 3 Complement Low C3 and C4 4 Low C3 or C4 3 Anti-phospholipid Anti-Cardiolipin or anti-β2-GPI or lupus anticoagulant 2 Constitutional Fever 2 Sensitivity was close to the SLICC 2012 criteria, specificity maintained at the level of the ACR 1997 criteria. This performance was independently confirmed in the validation cohort. ACR 1997 criteria SLICC criteria New criteria Derivation Sensitivity 84.63 96.81 98.00 Specificity 95.20 90.00 96.40 Validation Sensitivity 82.76 96.70 96.12 Specificity 93.38 83.62 93.38 Conclusions The new criteria developed with EULAR/ACR support achieved sensitivity close to the SLICC criteria, while maintaining the specificity of the ACR criteria. References [1] Aringer, et al. Ann Rheum Dis2017;76(S2):4. [2] Tedeschi, et al. Ann Rheum Dis2017;76(S2):50. Disclosure of Interest None declared
Published in
WEDNESDAY, 13 JUNE 2018
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