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AB0274 Association of serum pentosidine levels with intima media thickness in patients with rheumatoid arthritis
17 auth. M. Kerkeni, I. Knani, O. B. O. Sioud, H. Bouzidi, S. Zrour, S. Hammami, M. Hammami, N. Roodenrijs, M. D. Hair, G. Wheater, ...
Background Advanced glycation end products (AGEs) are formed by a nonenzymatic glycation process. Previously, we showed that pentosidine, as AGEs, was related to the severity of coronary artery disease (Kerkeni et al. 2014). Recently, we showed that…
Background Advanced glycation end products (AGEs) are formed by a nonenzymatic glycation process. Previously, we showed that pentosidine, as AGEs, was related to the severity of coronary artery disease (Kerkeni et al. 2014). Recently, we showed that AGEs are involved with disease activity in rheumatoid arthritis (RA) (Knani et al. 2017, 2018). No study about the relationship between serum pentosidine levels and intima media thickness (IMT) was evaluated. Objectives We aim to study the association of serum pentosidine levels with IMT in RA patients. Methods Our study included 30 control subjects and 40 patients with RA. The carotid IMT was measured using ultrasonography and serum pentosidine levels were determined by ELISA kit. Results Serum pentosidine levels were increased in RA patients vs control subjects (p<0.001) and were increased with disease activity score (DAS28) (p<0.001). IMT was increased with disease activity in RA patients (p<0.01) and was positively associated with serum pentosidine levels (p<0.001). Conclusions Serum pentosidine levels were increased with DAS28 and were associated with carotid IMT. References [1] Kerkeni M, Weiss IS, Jaisson S, et al. Increased serum concentrations of pentosidine are related to presence and severity of coronary artery disease. Thromb Res. 2014; 134:633–8. [2] Knani I, Bouzidi H, Zrour S, Bergaoui N, Hammami M, Kerkeni M. Increased serum concentrations of Nɛ-carboxymethyllysine are related to the presence and the severity of rheumatoid arthritis. Ann Clin Biochem2017(In Press). [3] Knani I, Bouzidi H, Zrour S, Bergaoui N, Hammami M, Kerkeni M. Methylglyoxal, a relevant marker of disease activity in patients with rheumatoid arthritis. Dis. Markers2018 (In Press). Disclosure of Interest None declared
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