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Title	Claps	Level	Year	L/Y
Chronic Traumatic Encephalopathy Jesse B. Mez, R. Stern, A. Mckee mental risk factors has often been a suspected trigger for the development of neurodegenerative disease. Yet of all the possible environmental risk factors put forth, trauma to the central nervous system is one of the most consistent candi dates for… mental risk factors has often been a suspected trigger for the development of neurodegenerative disease. Yet of all the possible environmental risk factors put forth, trauma to the central nervous system is one of the most consistent candi dates for initiating the molecular cascades that result in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis [1-3]. Recent evidence also suggests that mild traumatic brain injury (TBI), including repetitive concussive and subconcussive trauma, can provoke another distinctive neurodegeneration: chronic traumatic encephalopathy (CTE) [4]. CTE has to date only been described neuro pathologically in individuals with a history of repetitive closed head injury, most often occurring in the context of contact sports. It remains to be determined whether there is a genetic susceptibility to the development of CTE and whether a single severe traumatic head injury may also be causative. Published in Seminars in neurology	7	7	2020