| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
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Strong association of MuSK antibody–positive myasthenia gravis and HLA-DR14-DQ5
9 auth. E. Niks, J. Kuks, B. Roep, G. Haasnoot, W. Verduijn, B. Ballieux, ...
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody–positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 × 10−5). Fifty-two p…
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody–positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 × 10−5). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 × 10−8). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.
Published in
Neurology
|
14
|
7 | 2006 |
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