| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
|
Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
10 auth. T. Kündig, M. Bachmann, C. DiPaolo, J. Simard, M. Battegay, H. Lother, ...
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte res…
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
Published in
Science
|
30
|
8 | 1995 |
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