| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
|
Novel Delivery Strategies for Glioblastoma
Jiangbing Zhou, K. Atsina, Benjamin T. Himes, G. Strohbehn, W. M. Saltzman
AbstractBrain tumors—particularly glioblastoma multiforme—pose an important public health problem in the United States. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy is insuffi…
AbstractBrain tumors—particularly glioblastoma multiforme—pose an important public health problem in the United States. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy is insufficient with nearly universal recurrence. A major reason for this failure is the difficulty of delivering therapeutic agents to the brain: better delivery approaches are needed to improve treatment. In this article, we summarize recent progress in drug delivery to the brain, with an emphasis on convection-enhanced delivery of nanocarriers. We examine the potential of new delivery methods to permit novel drug- and gene-based therapies that target brain cancer stem cells and discuss the use of nanomaterials for imaging of tumors and drug delivery.
Published in
Cancer Journal
|
3
|
6 | 2012 |
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