| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
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Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
24 auth. Z. Zhang, T. Schuler, M. Zupancic, S. Wietgrefe, K. Staskus, K. Reimann, T. Reinhart, M. Rogan, W. Cavert, C. Miller, ...
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid…
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.
Published in
Science
|
113
|
9 | 1999 |
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