BetterScholar BetterScholar
Title Claps Level Year L/Y
Edinburgh Research Explorer Common variants at 10 genomic loci influence hemoglobin A(C) levels via glycemic and nonglycemic pathways
82 auth. Inga, Prokopenko, E. Stolerman, P. Muredach, Reilly, B. Voight, C. Willenborg, Knut, Krohn, Brigitte, Kühnel, Johanna, Kuusisto, M. Laakso, M. Lathrop, ... C. Lecoeur, Ruth J. F. Loos, J. Luan, Valeriya, Lyssenko, R. Mägi, A. Mälarstig, M. Mangino, Winfried März, W. McArdle, Ruth, McPherson, Christa, Meisinger, Olle Melander, K. Mohlke, E. Vincent, Mooser, M. Morken, Narisu Narisu, M. David, Nathan, M. Nauck, C. O’Donnell, Konrad, Oexle, Nazario, Olla, James, Pankow, Felicity, Payne, J. Peden, Nancy L Pedersen, Leena, Peltonen, Markus, Perola, Ozren, Polašek, Eleonora Porcu, Daniel J. Rader, S. Ripatti, G. Rocheleau, Richa, Saxena, K. Stefánsson, P. David, Strachan, R. Strawbridge, M. Stumvoll, Ida, Surakka, Gianluca, Usala, D. Waterworth, Hugh Watkins, G. Willemsen, Juliane, Winkelmann, Stephen E. Epstein, Jeanette, Erdmann, R. Sladek, Leif, Groop, W. H. Kao
OBJECTIVE— Glycated hemoglobin (HbA 1c ), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turn- over, and abnormal glycation of hemoglobin could also be assoc…
OBJECTIVE— Glycated hemoglobin (HbA 1c ), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turn- over, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA 1c . We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA 1c levels. RESEARCH DESIGN AND METHODS— We studied associa- tions with HbA 1c in up to 46,368 nondiabetic adults of European descent from 23 genome-wide association studies (GWAS) and 8 cohorts with de novo genotyped single nucleotide polymorphisms (SNPs). We combined studies using inverse-variance meta-analysis and tested mediation by glycemia using conditional analyses. We estimated the global effect of HbA 1c loci using a multilocus risk score, and used net reclassification to estimate genetic effects on diabetes screening. RESULTS— Ten loci reached genome-wide significant associa- tion with HbA 1c , including six new loci near FN3K (lead SNP/ P value, rs1046896/ P (cid:1) 1.6 (cid:2) 10 (cid:3) 26 ), HFE (rs1800562/ P (cid:1) 2.6 (cid:2) and four We show that
0
 0 2018