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Continuous Positive Airway Pressure Ventilation for Acute Ischemic Stroke: A Randomized Feasibility Study
11 auth. J. Minnerup, M. Ritter, Heike Wersching, André Kemmling, A. Okegwo, Antje Schmidt, ...
Background and Purpose— Sleep-related breathing disorders occur frequently after stroke. We assessed the feasibility of continuous positive airway pressure (CPAP) treatment initiated in the first night after stroke. Methods— In this open-label, para…
Background and Purpose— Sleep-related breathing disorders occur frequently after stroke. We assessed the feasibility of continuous positive airway pressure (CPAP) treatment initiated in the first night after stroke. Methods— In this open-label, parallel-group trial, 50 patients were randomly assigned to the CPAP therapy or to the control group. All patients underwent polysomnography in the fourth night. Intervention patients received CPAP therapy for 3 nights starting the first night after stroke onset and for an additional 4 nights when polysomnography revealed an apnea–hypopnea index >10/hour. The primary end point was feasibility defined as apnea–hypopnea index reduction under CPAP treatment, nursing workload, and CPAP adherence. Results— The apnea–hypopnea index under CPAP treatment was significantly reduced (32.2±25.3–9.8±6.6, P=0.0001). Nursing workload did not significantly differ between the CPAP (n=25) and the control group (n=25; P=0.741). Ten patients (40.0%) had excellent CPAP use, 14 patients (56.0%) had some use, and 1 patient (4.0%) had no use. There was a trend toward greater National Institutes of Health Stroke Scale score improvement until Day 8 in patients on CPAP (2.00 versus 1.40, P=0.092) and a significantly greater National Institutes of Health Stroke Scale score improvement in patients with excellent CPAP use when compared with control patients (2.30 versus 1.40, P=0.022). Conclusions— CPAP therapy initiated in the first night after stroke seems to be feasible and was not associated with neurological deterioration. Clinical Trial Registration— URL: www.clinicaltrials.gov. Unique identifier: NCT00151177.
Published in
Stroke
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5
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6 | 2012 |
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