| Title | Claps | Level | Year | L/Y |
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Visible-Light-Promoted C(sp3)-H Alkylation by Intermolecular Charge Transfer: Preparation of Unnatural α-Amino Acids and Late-stage Modification of Peptides.
8 auth. Chao Wang, Rupeng Qi, H. Xue, Yuxuan Shen, M. Chang, Yaqiong Chen, ...
Disclosed herein is the visible-light promoted deaminative C(sp3)-H alkylation of glycine and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent functional-group tolerance provided a general strategy for the ef…
Disclosed herein is the visible-light promoted deaminative C(sp3)-H alkylation of glycine and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent functional-group tolerance provided a general strategy for the efficient preparation of unnatural α-amino acids and precise modification of peptide with unnatural α-amino acid residues. Mechanistic studies suggest that visible-light promoted intermolecular charge transfer within glycine-Katritzky salt EDA complex induced a SET process without the assistance of photocatalyst.
Published in
Angewandte Chemie
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2
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6 | 2020 |
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