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GIMAP and Behçet disease: no association in the European population
18 auth. L. Ortiz-Fernández, M. Conde-Jaldón, J. García-Lozano, M. Montes-Cano, N. Ortego-Centeno, M. Castillo-Palma, G. Espinosa, G. Graña-Gil, J. Sánchez-Bursón, M. González-Gay, ...
Behcet disease (BD) is a multifactorial disorder with a highest prevalence among people with Mediterranean or Asian ancestry having association with HLA-B51 and other HLA and non-HLA loci.1–4 Very recently, one genome-wide association study (GWAS) i…
Behcet disease (BD) is a multifactorial disorder with a highest prevalence among people with Mediterranean or Asian ancestry having association with HLA-B51 and other HLA and non-HLA loci.1–4 Very recently, one genome-wide association study (GWAS) identified the GIMAP locus, which encoded proteins involved in development of the T and B lymphocytes, as associated with the disease in the Asian populations.5 To investigate whether this association is replicated in Europeans, a total of 1086 (326 patients and 760 controls) Spanish individuals of European origin were genotyped after obtaining written informed consent and approval from the local ethical committees of all the institutions involved. Patients fulfilled the 1990 International Study Group classification criteria for Behcet’s disease,6 and the group was composed of 44.5% men with the following clinical features: 100% had oral ulcers, 63.6% genital ulcers, 58.7% uveitis, 48% arthritis, 20.2% vascular, 21.9% neurological and 19.2% gastrointestinal involvement. Regarding HLA association, in addition to B*51 (p<10−7, OR=4.11, 95% CI 2.79 to 6.06), B*57 was found to be risk factor in this cohort with an OR similar to that provided by B*51 …
Published in
Annals of the Rheumatic Diseases
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6
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4 | 2014 |
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