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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
142 auth. Renzo Mancuso, Gemma L. Fryatt, Madeleine Cleal, J. Obst, E. Pipi, Jimena Monzón-Sandoval, Elena Ribe, L. Winchester, C. Webber, Alejo J. Nevado, T. Jacobs, N. Austin, C. Theunis, Karolien Grauwen, Eva Daniela Ruiz, ... A. Mudher, Marta Vicente-Rodríguez, Christine A Parker, C. Simmons, Diana Cash, Jill C Richardson, E. Bullmore, Junaid Bhatti, Samuel J. Chamberlain, M. Correia, Anna L. Crofts, A. Dickinson, A. Foster, M. Kitzbichler, Clare Knight, M. Lynall, Christina Maurice, Ciara O’Donnell, L. Pointon, P. Hyslop, L. Turner, P. Vértes, B. Widmer, G. Williams, B. Morgan, C. Leckey, A. Morgan, C. O’Hagan, Samuel Touchard, J. Cavanagh, Catherine Deith, Scott J. Farmer, J. Mcclean, A. McColl, Andrew McPherson, Paul Scouller, Murray Sutherland, H. Boddeke, Jill C Richardson, Shahid Khan, Phil Murphy, Christine A Parker, Jai Patel, Declan N C Jones, P. de Boer, J. Kemp, W. Drevets, J. Nye, G. Wittenberg, J. Isaac, A. Bhattacharya, N. Carruthers, H. Kolb, C. Pariante, F. Turkheimer, G. Barker, H. Byrom, Diana Cash, A. Cattaneo, Antony D. Gee, C. Hastings, N. Mariani, A. McLaughlin, V. Mondelli, M. Nettis, N. Nikkheslat, K. Randall, Hannah Sheridan, C. Simmons, Nisha Singh, V. V. Loo, Marta Vicente-Rodríguez, Tobias C. Wood, C. Worrell, Z. Zajkowska, N. Plath, J. Egebjerg, H. Eriksson, F. Gastambide, Karen H. Adams, R. Jeggo, Christian Thomsen, J. Pederson, B. Campbell, T. Möller, Bob Nelson, S. Zorn, Jason O’Connor, M. Attenburrow, A. Baird, Jithen Benjamin, S. Clare, Philip A. Cowen, I. Huang, Sam Hurley, Helen Jones, Simon Lovestone, Francisca Mada, A. Nevado-Holgado, Akintayo Oladejo, Elena Ribe, Katy Smith, Anviti Vyas, Zoe Hughes, R. Balice-Gordon, J. Duerr, Justin R. Piro, J. Sporn, V. Hugh Perry (PI, Madeleine Cleal, Gemma L. Fryatt, Diego Gomez-Nicola, Renzo Mancuso, Richard Reynolds, N. Harrison, M. Cercignani, Charlotte L Clarke, E. Hoskins, C. Kohn, Rosemary Murray, Lauren Wilcock, Dominika Wlazły, H. Mount, Declan N C Jones, Simon Lovestone, Diego Gomez-Nicola, V. Perry
Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifies brain in…
Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifies brain inflammation and ameliorates disease progression in P301S tauopathy mice. CSF1R inhibition may have therapeutic potential in tau-mediated neurodegenerative diseases.
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7 2019