Title | Claps | Level | Year | L/Y |
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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
142 auth. Renzo Mancuso, Gemma L. Fryatt, Madeleine Cleal, J. Obst, E. Pipi, Jimena Monzón-Sandoval, Elena Ribe, L. Winchester, C. Webber, Alejo J. Nevado, T. Jacobs, N. Austin, C. Theunis, Karolien Grauwen, Eva Daniela Ruiz, ...
Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifies brain in…
Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifies brain inflammation and ameliorates disease progression in P301S tauopathy mice. CSF1R inhibition may have therapeutic potential in tau-mediated neurodegenerative diseases.
Published in
Brain : a journal of neurology
|
20
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7 | 2019 |
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