| Title | Claps | Level | Year | L/Y |
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Survival analysis of presumptive prognostic markers among oligodendrogliomas
10 auth. R. McLendon, J. Herndon, B. West, D. Reardon, R. Wiltshire, B. Rasheed, ...
Allelic losses of 1p and 19q arms correlate with the oligodendroglial phenotype as well as with sensitivity to radiotherapy and chemotherapy. Furthermore, the DNA repair gene, methylguanine methyltransferase (MGMT), is diminished in 80% of oligodend…
Allelic losses of 1p and 19q arms correlate with the oligodendroglial phenotype as well as with sensitivity to radiotherapy and chemotherapy. Furthermore, the DNA repair gene, methylguanine methyltransferase (MGMT), is diminished in 80% of oligodendroglial tumors and represents a possible mechanism for this therapeutic sensitivity. However, the authors questioned the relevance of genetic testing and measuring MGMT levels in tumors that were diagnostic of oligodendroglioma.
Published in
Cancer
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4
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5 | 2005 |
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