BetterScholar BetterScholar
Title Claps Level Year L/Y
Genomic epidemiology of the current wave of artemisinin resistant malaria
95 auth. R. Amato, Olivo Miotto, C. Woodrow, Jacob Almagro-Garcia, I. Sinha, S. Campino, D. Mead, Eleanor Drury, M. Kekre, M. Sanders, A. Amambua-Ngwa, C. Amaratunga, L. Amenga-Etego, T. Anderson, V. Andrianaranjaka, ... T. Apinjoh, E. Ashley, Sarah Auburn, G. Awandare, Vito Baraka, A. Barry, M. F. Boni, S. Borrmann, T. Bousema, O. Branch, Peter Bull, K. Chotivanich, D. Conway, A. Craig, N. Day, A. Djimde, C. Dolecek, A. Dondorp, C. Drakeley, P. Duffy, Diego F Echeverri-Garcia, T. Egwang, R. Fairhurst, A. Faiz, C. Fanello, T. Hien, A. Hodgson, M. Imwong, D. Ishengoma, Pharath Lim, Chanthap Lon, J. Marfurt, K. Marsh, M. Mayxay, V. Mobegi, O. Mokuolu, J. Montgomery, I. Mueller, M. P. Kyaw, P. Newton, F. Nosten, Rintis Noviyanti, A. Nzila, Harold Ocholla, A. Oduro, M. Onyamboko, J. Ouédraogo, A. Phyo, C. Plowe, R. Price, S. Pukrittayakamee, M. Randrianarivelojosia, P. Ringwald, Lastenia Ruiz, D. Saunders, Alex Shayo, P. Siba, Shannon Takala-Harrison, Thuy Nguyen Thanh, Vandana Thathy, F. Verra, N. White, Y. Htut, Victoria J Cornelius, Rachel Giacomantonio, Dawn Muddyman, Christa Henrichs, Cinzia Malangone, D. Jyothi, R. Pearson, J. Rayner, G. McVean, K. Rockett, A. Miles, P. Vauterin, Ben Jeffery, M. Manske, J. Stalker, B. MacInnis, D. Kwiatkowski
Artemisinin resistant Plasmodium falciparum is advancing across Southeast Asia in a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeas…
Artemisinin resistant Plasmodium falciparum is advancing across Southeast Asia in a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of standing variation that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelch13 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.
Published in bioRxiv
0
 2 2015