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Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease
154 auth. G. Jun, G. Beecham, Li-San Wang, B. Vardarajan, Jacqueline Buros, P. Gallins, J. Buxbaum, G. Jarvik, P. Crane, E. Larson, T. Bird, B. Boeve, N. Graff-Radford, P. D. Jager, D. Evans, ... J. Schneider, M. Carrasquillo, N. Ertekin-Taner, S. Younkin, Carlos Cruchaga, J. Kauwe, P. Nowotny, P. Kramer, J. Hardy, M. Huentelman, A. Myers, M. Barmada, F. Y. Demirci, C. Baldwin, R. Green, E. Rogaeva, P. George-Hyslop, S. Arnold, R. Barber, T. Beach, E. Bigio, J. Bowen, A. Boxer, J. Burke, N. Cairns, C. Carlson, R. Carney, S. Carroll, H. Chui, D. G. Clark, Jason J. Corneveaux, C. Cotman, J. Cummings, C. DeCarli, S. DeKosky, R. Diaz-Arrastia, M. Dick, D. Dickson, W. Ellis, K. Faber, K. Fallon, M. Farlow, S. Ferris, M. Frosch, D. Galasko, M. Ganguli, M. Gearing, D. Geschwind, B. Ghetti, J. Gilbert, S. Gilman, B. Giordani, J. Glass, J. Growdon, R. Hamilton, L. Harrell, E. Head, L. Honig, C. Hulette, B. Hyman, G. Jicha, Lee‐way Jin, N. Johnson, J. Karlawish, A. Karydas, J. Kaye, R. Kim, E. Koo, N. Kowall, J. Lah, A. Levey, A. Lieberman, O. Lopez, W. Mack, D. Marson, F. Martiniuk, D. Mash, E. Masliah, W. McCormick, S. McCurry, A. McDavid, A. Mckee, M. Mesulam, B. Miller, C. Miller, Joshua W. Miller, J. Parisi, D. Perl, E. Peskind, R. Petersen, W. Poon, J. Quinn, Ruchita A Rajbhandary, M. Raskind, B. Reisberg, J. Ringman, E. Roberson, R. Rosenberg, M. Sano, L. Schneider, W. Seeley, M. Shelanski, M. Slifer, Charles D. Smith, J. Sonnen, S. Spina, R. Stern, R. Tanzi, J. Trojanowski, J. Troncoso, V. Deerlin, H. Vinters, J. Vonsattel, S. Weintraub, K. Welsh-Bohmer, J. Williamson, R. Woltjer, L. Cantwell, B. Dombroski, D. Beekly, K. Lunetta, E. Martin, M. Kamboh, A. Saykin, E. Reiman, D. Bennett, J. Morris, T. Montine, A. Goate, D. Blacker, D. Tsuang, H. Hakonarson, W. Kukull, T. Foroud, J. Haines, R. Mayeux, M. Pericak-Vance, L. Farrer, G. Schellenberg
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage ) and two replication stages (stages 2 and 3). Both joint an…
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage ) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages and 2, meta-analysis P (PM) = .7 × 0, joint analysis P (PJ) = .7 × 0−9; stages , 2 and 3, PM = 8.2 × 0− 2), CD2AP (rs9349407; stages , 2 and 3, PM = 8.6 × 0−9), EPHA1 (rs 767557; stages , 2 and 3, PM = 6.0 × 0− 0) and CD33 (rs3865444; stages , 2 and 3, PM = .6 × 0−9). We also replicated previous associations at CR1 (rs670 7 3; PM = 4.6 × 0− 0, PJ = 5.2 × 0− ), CLU (rs 532278; PM = 8.3 × 0, PJ = .9 × 0−8), BIN1 (rs756 528; PM = 4.0 × 0− , PJ = 5.2 × 0− 4) and PICALM (rs56 655; PM = 7.0 × 0− , PJ = .0 × 0− 0), but not at EXOC3L2, to late-onset Alzheimer’s disease susceptibility –3.
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 7 2011