| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
|
Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention.
11 auth. C. Hastie, S. Padmanabhan, R. Slack, A. Pell, K. Oldroyd, A. Flapan, ...
AIMS
We sought to investigate the impact of body mass index (BMI) on long-term all-cause mortality in patients following first-time elective percutaneous coronary intervention (PCI).
METHODS AND RESULTS
We used the Scottish Coronary Revascularisat…
AIMS
We sought to investigate the impact of body mass index (BMI) on long-term all-cause mortality in patients following first-time elective percutaneous coronary intervention (PCI).
METHODS AND RESULTS
We used the Scottish Coronary Revascularisation Register to undertake a cohort study of all patients undergoing elective PCI in Scotland between April 1997 and March 2006 inclusive. We excluded patients who had previously undergone revascularization. There were 219 deaths within 5 years of 4880 procedures. Compared with normal weight individuals, those with a BMI > or =27.5 and <30 were at reduced risk of dying (HR 0.59, 95% CI 0.39-0.90, 95%, P = 0.014). There was no attenuation of the association after adjustment for potential confounders, including age, hypertension, diabetes, and left ventricular function (adjusted HR 0.59, 95% CI 0.39-0.90, P = 0.015), and there were no statistically significant interactions. The results were unaltered by restricting the analysis to events beyond 30 days of follow-up.
CONCLUSION
Among patients undergoing percutaneous intervention for coronary artery disease, increased BMI was associated with improved 5 year survival. Among those with established coronary disease, the adverse effects of excess adipose tissue may be offset by beneficial vasoactive properties.
Published in
European Heart Journal
|
9
|
7 | 2010 |
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