Title | Claps | Level | Year | L/Y |
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Scope and Limitations
73 auth. W. Alvey, F. Scheuren, Alvey, Wendy, G. Wagner, Newcombe, D. Flaherty, Edward H. Hanis, Mitchell, Us, Tiné, S. Livingstone, Aziz, Faye, Qualit Yof, ...
As a consequence of the importance of nitrogen-containing compounds in biological and pharmaceutical applications, methods for the construction of carbon-nitrogen bonds have been heavily studied for at least 150 years. Hydroamination, the addition o…
As a consequence of the importance of nitrogen-containing compounds in biological and pharmaceutical applications, methods for the construction of carbon-nitrogen bonds have been heavily studied for at least 150 years. Hydroamination, the addition of HNR2 across a carbon-carbon π bond, is in principle one of the most atom-economical methods for the synthesis of this class of compounds. Catalytic hydroaminations of alkenes, allenes, and dienes (which may be interor intramolecular) afford amines, imines, and enamines (Eq. 1).
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1
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5 | 2000 |
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