| Title | Claps | Level | Year | L/Y |
|---|---|---|---|---|
|
The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons
Galit Lev-Maor, R. Sorek, N. Shomron, G. Ast
Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analy…
Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analyzed a data set of human exonized Alus. We revealed a mechanism that governs 3′ splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu.
Published in
Science
|
39
|
8 | 2003 |
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